Journal article Open Access

Multiple sclerosis: Excess of Cytoplasmic Steroid Receptors to Corresponding Hormones in the Oligodendrocytes

Ebbe Lundsgaard*


MARC21 XML Export

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="041" ind1=" " ind2=" ">
    <subfield code="a">eng</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Keywords: Multiple-sclerosis; Oligodendrocytes; Steroid-receptors; Steroid-hormones; Vitamin-D; Estrogen.</subfield>
  </datafield>
  <controlfield tag="005">20200725005922.0</controlfield>
  <controlfield tag="001">3959103</controlfield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">613327</subfield>
    <subfield code="z">md5:94bf47255765ed6e5edf802ef31f03e4</subfield>
    <subfield code="u">https://zenodo.org/record/3959103/files/JMSS-02-0024.pdf</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2020-07-03</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">openaire</subfield>
    <subfield code="o">oai:zenodo.org:3959103</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="c">1-7</subfield>
    <subfield code="n">2</subfield>
    <subfield code="p">Journal of Medicine and Surgical Sciences</subfield>
    <subfield code="v">2</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">M.D. Skolemarken 32, Broballe, 6430 Nordborg, Denmark</subfield>
    <subfield code="a">Ebbe Lundsgaard*</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Multiple sclerosis: Excess of Cytoplasmic Steroid Receptors to Corresponding Hormones in the Oligodendrocytes</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield>
    <subfield code="a">Creative Commons Attribution 4.0 International</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;&lt;strong&gt;Abstract&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;An excess of zinc-enriched type 1 steroid receptors to matching steroid hormones may damage oligodendrocytes and cause central nervous system demyelination and multiple sclerosis. These receptors for vitamin D, estrogens, androgens, and other steroids can form cytoplasmic aggregates that occasionally release zinc in larger amounts, causing hyperphosphorylation of tau protein and degradation of the oligodendrocytes and the myelin sheath around the neurons.Postmenopausal women and older men with multiple sclerosis and a hereditary low sex hormone level matched by excess receptors may develop symptoms of Alzheimer&amp;rsquo;s.&lt;/p&gt;

&lt;p&gt;Six facts about multiple sclerosis were inserted into innovative differential equations for the construction of the graphs, which show: A simultaneous increase in vitamin D receptors and multiple sclerosis. Vitamin D receptors are exposed to negative feedback from vitamin D followed by positive feedback from estrogen, which is initially repressed by vitamin D. Thus, growing levels of estrogen increase vitamin D receptors, while high levels in multiple sclerosis-pregnancies reduce the detrimental effect of vitamin D receptors by additional bonds to estrogen receptors, obviously augmented by a terminal drop in vitamin D receptors.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="n">doi</subfield>
    <subfield code="i">isVersionOf</subfield>
    <subfield code="a">10.5281/zenodo.3959102</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.5281/zenodo.3959103</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
</record>
224
190
views
downloads
All versions This version
Views 224224
Downloads 190190
Data volume 116.5 MB116.5 MB
Unique views 200200
Unique downloads 176176

Share

Cite as