Journal article Open Access

Multiple sclerosis: Excess of Cytoplasmic Steroid Receptors to Corresponding Hormones in the Oligodendrocytes

Ebbe Lundsgaard*

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  <identifier identifierType="DOI">10.5281/zenodo.3959103</identifier>
      <creatorName>Ebbe Lundsgaard*</creatorName>
      <affiliation>M.D. Skolemarken 32, Broballe, 6430 Nordborg, Denmark</affiliation>
    <title>Multiple sclerosis: Excess of Cytoplasmic Steroid Receptors to Corresponding Hormones in the Oligodendrocytes</title>
    <subject>Keywords: Multiple-sclerosis; Oligodendrocytes; Steroid-receptors; Steroid-hormones; Vitamin-D; Estrogen.</subject>
    <date dateType="Issued">2020-07-03</date>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
    <alternateIdentifier alternateIdentifierType="url"></alternateIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.3959102</relatedIdentifier>
    <rights rightsURI="">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
    <description descriptionType="Abstract">&lt;p&gt;&lt;strong&gt;Abstract&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;An excess of zinc-enriched type 1 steroid receptors to matching steroid hormones may damage oligodendrocytes and cause central nervous system demyelination and multiple sclerosis. These receptors for vitamin D, estrogens, androgens, and other steroids can form cytoplasmic aggregates that occasionally release zinc in larger amounts, causing hyperphosphorylation of tau protein and degradation of the oligodendrocytes and the myelin sheath around the neurons.Postmenopausal women and older men with multiple sclerosis and a hereditary low sex hormone level matched by excess receptors may develop symptoms of Alzheimer&amp;rsquo;s.&lt;/p&gt;

&lt;p&gt;Six facts about multiple sclerosis were inserted into innovative differential equations for the construction of the graphs, which show: A simultaneous increase in vitamin D receptors and multiple sclerosis. Vitamin D receptors are exposed to negative feedback from vitamin D followed by positive feedback from estrogen, which is initially repressed by vitamin D. Thus, growing levels of estrogen increase vitamin D receptors, while high levels in multiple sclerosis-pregnancies reduce the detrimental effect of vitamin D receptors by additional bonds to estrogen receptors, obviously augmented by a terminal drop in vitamin D receptors.&lt;/p&gt;</description>
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