{ "access": { "embargo": { "active": false, "reason": null }, "files": "public", "record": "public", "status": "open" }, "created": "2020-07-03T13:14:48.794022+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "files": { "count": 1, "enabled": true, "entries": { "mpro_tanimoto.tar.xz": { "checksum": "md5:66a0362049db0243632d4121bce43e39", "ext": "xz", "id": "868fb241-8fc1-401e-be27-1fae0e495fd8", "key": "mpro_tanimoto.tar.xz", "metadata": null, "mimetype": "application/x-xz", "size": 10826687140 } }, "order": [], "total_bytes": 10826687140 }, "id": "3929438", "is_draft": false, "is_published": true, "links": { "access": "https://zenodo.org/api/records/3929438/access", "access_links": "https://zenodo.org/api/records/3929438/access/links", "access_request": "https://zenodo.org/api/records/3929438/access/request", "access_users": "https://zenodo.org/api/records/3929438/access/users", "archive": "https://zenodo.org/api/records/3929438/files-archive", "archive_media": "https://zenodo.org/api/records/3929438/media-files-archive", "communities": "https://zenodo.org/api/records/3929438/communities", "communities-suggestions": "https://zenodo.org/api/records/3929438/communities-suggestions", "doi": "https://doi.org/10.5281/zenodo.3929438", "draft": "https://zenodo.org/api/records/3929438/draft", "files": "https://zenodo.org/api/records/3929438/files", "latest": "https://zenodo.org/api/records/3929438/versions/latest", "latest_html": "https://zenodo.org/records/3929438/latest", "media_files": "https://zenodo.org/api/records/3929438/media-files", "parent": "https://zenodo.org/api/records/3929437", "parent_doi": "https://zenodo.org/doi/10.5281/zenodo.3929437", "parent_html": "https://zenodo.org/records/3929437", "requests": "https://zenodo.org/api/records/3929438/requests", "reserve_doi": "https://zenodo.org/api/records/3929438/draft/pids/doi", "self": "https://zenodo.org/api/records/3929438", "self_doi": "https://zenodo.org/doi/10.5281/zenodo.3929438", "self_html": "https://zenodo.org/records/3929438", "self_iiif_manifest": "https://zenodo.org/api/iiif/record:3929438/manifest", "self_iiif_sequence": "https://zenodo.org/api/iiif/record:3929438/sequence/default", "versions": "https://zenodo.org/api/records/3929438/versions" }, "media_files": { "count": 0, "enabled": false, "entries": {}, "order": [], "total_bytes": 0 }, "metadata": { "creators": [ { "affiliations": [ { "name": "Utrecht University" } ], "person_or_org": { "family_name": "P. I. Koukos", "name": "P. I. Koukos", "type": "personal" } }, { "affiliations": [ { "name": "Utrecht University" } ], "person_or_org": { "family_name": "M. R\u00e9au", "identifiers": [ { "identifier": "0000-0002-3862-8990", "scheme": "orcid" } ], "name": "M. R\u00e9au", "type": "personal" } }, { "affiliations": [ { "name": "Utrecht University" } ], "person_or_org": { "family_name": "A. M. J. J. Bonvin", "identifiers": [ { "identifier": "0000-0001-7369-1322", "scheme": "orcid" } ], "name": "A. M. J. J. Bonvin", "type": "personal" } } ], "description": "
The novel coronavirus (SARS-CoV-2) that has emerged from Wuhan, China in December 2019 has spread to almost all countries in the world causing a dramatic number of deaths. The current absence of antiviral treatment against the SARS-CoV-2 urges the scientific community to accelerate the drug discovery research process.
\n\nOne way to identify potential treatments and to be able to administer it swiftly is to focus on drug repurposing studies, i.e. to investigate the SARS-CoV-2 antiviral potential of drugs that have already been approved for human use.
\n\nProteins that are crucial for the survival and replication of the virus are the most attractive targets for such studies. Here we have focused on the SARS-CoV-2 main protease (3CLpro) that plays an essential role in the virus replication process by screening ~2000 approved drugs (and 6 experimental ones) against this particular protein using a shape-based assay.
\n\nThis is one part of a multi-target screen emphasising the main protease (Mrpo), the RNA-dependent-RNA-polymerase (RdRp) and human ACE2. The other datasets can found at the following locations:
\n\nMore information about this screen along with interactive visualisations of the top compounds can be found on our website bonvinlab.org.
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\r\n\r\nOnly records that may be relevant to the Corona Virus Disease (COVID-19) or the SARS-CoV-2 should be included in this community. The Community curators are not able to edit records, therefore they may ask the corresponding authors to modify the record metadata when necessary, to provide the readers/users with more detailed information according to the FAIR principle of Open Science.
\r\n\r\nIf after its acceptance, a record is subsequently found not to be compliant, we reserve the right to remove it from the community.
\r\n\r\nThe curation team is reachable through the following email address for further clarification or information: covid19@openaire.eu.
\r\n\r\nCurator List:
\r\n\r\n* OpenAIRE: open access and open science training and support since 2009. OpenAIRE is the largest aggregator of European Commission funded research outputs and beyond, also delivering on-demand services for research communities.
\r\n", "page": "This community collects research outputs that may be relevant to the Coronavirus Disease (COVID-19) or the SARS-CoV-2. Scientists are encouraged to upload their outcome in this collection to facilitate sharing and discovery of information. Although Open Access articles and datasets are recommended, also closed and restricted access material are accepted. All types of research outputs can be included in this Community (Publication, Poster, Presentation, Dataset, Image, Video/Audio, Software, Lesson, Other).
\r\n\r\nThe recent Corona Virus Disease (COVID-19) outbreak is requiring unseen efforts of collaboration of the scientific community that need to act fast and to share results in an unpredictable manner. In order to facilitate the Scientist efforts, this community was created to collect all research results that could be relevant for the scientific community working on the Corona Virus Disease (COVID-19) and SARS-CoV-2.
\r\n\r\nAlthough Open Access articles and datasets are recommended, also closed and restricted access material are accepted. All types of research outputs can be included in this Community (Publication, Poster, Presentation, Dataset, Image, Video/Audio, Software, Lesson, Other).
\r\n\r\nWhen depositing a resource that is linked to other resources (not limited to the records deposited in Zenodo but also in other repositories), please make sure that your record is linked to all the other related elements already available, in order to adhere to the FAIR principles of Open Science to maximise the reusability of research results.
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A community-driven data repository and curation service for molecular structures, models, therapeutics, and simulations related to computational research related to therapeutic opportunities for COVID-19 (caused by the SARS-CoV-2 coronavirus). For more info about the project, see the about page.
\r\n\r\nThe repository collects high-quality data related to:
\r\n\r\nThe EU Open Research Repository serves as a repository for research outputs (data, software, posters, presentations, publications, etc) which have been funded under an EU research funding programme such as Horizon Europe, Euratom or earlier Framework Programmes.
\nThe community is managed by CERN on behalf of the European Commission.
\nZenodo’s general policies and Terms of Use apply to all content.
\nThe EU Open Research Repository accepts all digital research objects which is a research output stemming from one of EU’s research and innovation funding programmes. The funding programmes currently include:
\nHorizon Europe (including ERC, MSCA), earlier Framework Programmes (eg Horizon 2020) as well as Euratom.
\nIn line with the principle as open as possible, as closed as necessary both public and restricted content is accepted. See note on how Zenodo handles restricted content.
\nEU programme beneficiaries are eligible to submit content to the community. The community supports three types of content submissions:
\nSubmission via an EU Project Community (through user interface or programmatic APIs).
\nSubmission directly to the EU Open Research Repository.
\nAutomated harvesting from existing Zenodo content.
\nA representative of an EU project may request an EU Project Community and invite other project participants as members of the community. The project community is linked to one or more European Commission grants. All records in the project community are automatically integrated into the EU Open Research Repository immediately upon acceptance into the project community.
\nAny user may submit a record directly to the EU Open Research Repository. The submission will be moderated by Zenodo staff for compliance with the minimal required metadata requirements and its correctness.
\nRecords found among Zenodo’s existing content will on a regular basis automatically be integrated if they are found to comply with the requirements. The submissions through this method are integrated into the EU Open Research Repository with delay in a fully automated way.
\nRecords in the EU Open Research Repository are required to comply with the following minimal metadata requirements:
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\nResource types: All resource types.
\nLicenses: Public and embargoed records MUST specify a license.
\nFunding information: Records MUST specify at least one grant from the European Commission.
\nCreators: Creators SHOULD be identified with a persistent identifier (e.g. ORCID, GND, …), and affiliations SHOULD be identified with a persistent identifier (e.g. ROR, ISNI, …)
\nSubjects: Records SHOULD specify one or more fields of science from the European Science Vocabulary.
\nAll submissions will undergo automated curation checks for compliance with the policy. Submissions through project communities are reviewed by the project community. Submission directly to the EU Open Research Repository is reviewed by Zenodo staff.
\nCommunity curators may at any point edit metadata of the records in the community without notice through human or automated processing. The curators may at their sole discretion remove records from the community that are deemed not to comply with the content and curation policy or which are deemed of insufficient quality.
\nThe content and curation policy is subject to change by the community owner at any time and without notice, other than through updating this page.
", "description": "Open repository for EU-funded research outputs from Horizon Europe, Euratom and earlier Framework Programmes.", "organizations": [ { "id": "00k4n6c32" } ], "page": "The EU Open Research Repository is a Zenodo-community dedicated to fostering open science and enhancing the visibility and accessibility of research outputs funded by the European Union. The community is managed by CERN on behalf of the European Commission.
\nThe mission of the repository is to support the implementation of the EU's open science policy, providing a trusted and comprehensive space for researchers to share their research outputs such as data, software, reports, presentations, posters and more. The EU Open Research Repository simplifies the process of complying with open science requirements, ensuring that research outputs from Horizon Europe, Euratom, and earlier Framework Programmes are freely accessible, thereby accelerating scientific discovery and innovation.
\nThe EU Open Research Repository serves as a complementary platform to the Open Research Europe (ORE) publishing platform. Open Research Europe focuses on providing a publishing venue for peer-reviewed articles, ensuring that research meets rigorous academic standards. The EU Open Research Repository provides a space for all the other research outputs including data sets, software, posters, and presentations that are out of scope for ORE. This holistic approach enables researchers to not only publish their findings but also share the underlying data and materials that support their work, fostering transparency and reproducibility in the scientific process.
\nCurrently in its pilot phase and set to be fully operational during autumn 2024, the EU Open Research Repository is constantly evolving. Efforts are committed to integrating cutting-edge features, including automated curation checks and FAIR (Findable, Accessible, Interoperable, and Reusable) assistance, to further support the research community. The goal is to provide researchers with a simple goto solution for making their publicly funded research open and as FAIR as possible.
\nThe EU Open Research Repository is funded by the European Union under grant agreement no. 101122956(HORIZON-ZEN). For more information about the project see https://about.zenodo.org/projects/horizon-zen/.
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\n\nBioExcel is funded by the European Union Horizon 2020 program under grant agreements 823830, 675728.
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