Journal article Open Access

Statistical review of Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report

Morris, Tim; Dahly, Darren; Hood, Kerry; Gates, Simon


DCAT Export

<?xml version='1.0' encoding='utf-8'?>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:adms="http://www.w3.org/ns/adms#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dct="http://purl.org/dc/terms/" xmlns:dctype="http://purl.org/dc/dcmitype/" xmlns:dcat="http://www.w3.org/ns/dcat#" xmlns:duv="http://www.w3.org/ns/duv#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:frapo="http://purl.org/cerif/frapo/" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:gsp="http://www.opengis.net/ont/geosparql#" xmlns:locn="http://www.w3.org/ns/locn#" xmlns:org="http://www.w3.org/ns/org#" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:prov="http://www.w3.org/ns/prov#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:schema="http://schema.org/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:vcard="http://www.w3.org/2006/vcard/ns#" xmlns:wdrs="http://www.w3.org/2007/05/powder-s#">
  <rdf:Description rdf:about="https://doi.org/10.5281/zenodo.3928540">
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://doi.org/10.5281/zenodo.3928540</dct:identifier>
    <foaf:page rdf:resource="https://doi.org/10.5281/zenodo.3928540"/>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Morris, Tim</foaf:name>
        <foaf:givenName>Tim</foaf:givenName>
        <foaf:familyName>Morris</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>MRC Clinical Trials Unit at University College London</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Dahly, Darren</foaf:name>
        <foaf:givenName>Darren</foaf:givenName>
        <foaf:familyName>Dahly</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>HRB Clinical Research Facility Cork. Senior Lecturer in Patient-Focused Research Methods, School of Public Health, University College Cork</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Hood, Kerry</foaf:name>
        <foaf:givenName>Kerry</foaf:givenName>
        <foaf:familyName>Hood</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Centre for Trials Research, Cardiff University</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Gates, Simon</foaf:name>
        <foaf:givenName>Simon</foaf:givenName>
        <foaf:familyName>Gates</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, UK</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:title>Statistical review of Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report</dct:title>
    <dct:publisher>
      <foaf:Agent>
        <foaf:name>Zenodo</foaf:name>
      </foaf:Agent>
    </dct:publisher>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2020</dct:issued>
    <dcat:keyword>COVID-19</dcat:keyword>
    <dcat:keyword>RCT</dcat:keyword>
    <dcat:keyword>Cinical trial</dcat:keyword>
    <dcat:keyword>Randomized controlled trial</dcat:keyword>
    <dcat:keyword>Dexamethasone</dcat:keyword>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2020-07-02</dct:issued>
    <dct:language rdf:resource="http://publications.europa.eu/resource/authority/language/ENG"/>
    <owl:sameAs rdf:resource="https://zenodo.org/record/3928540"/>
    <adms:identifier>
      <adms:Identifier>
        <skos:notation rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/3928540</skos:notation>
        <adms:schemeAgency>url</adms:schemeAgency>
      </adms:Identifier>
    </adms:identifier>
    <dct:isVersionOf rdf:resource="https://doi.org/10.5281/zenodo.3928539"/>
    <dct:isPartOf rdf:resource="https://zenodo.org/communities/covid-19-tx-rct-stats-review"/>
    <owl:versionInfo>1.0</owl:versionInfo>
    <dct:description>&lt;p&gt;The following review has been prepared in collaboration with members of the MRC-NIHR Trials Methodology Research Partnership. The reviewers named above, and other, unnamed discussants of the paper, are all qualified statisticians with experience in clinical&amp;nbsp; trials. Our objective is to provide a rapid review of publications, preprints and protocols from clinical trials of COVID-19 treatments,&amp;nbsp; independent of journal specific review processes. We aim to provide timely, constructive, focused, clear advice aimed at improving&amp;nbsp; both the research outputs under review, as well as future studies. Given our collective expertise (clinical trial statistics) our reviews&amp;nbsp; focus on the designs of the trials and other statistical content (methods, presentation and accuracy of results, inferences). This&amp;nbsp; review reflects the expert opinions of the named authors, and does not imply endorsement by the MRC-NIHR Trials Methodology&amp;nbsp; Research Partnership, its wider membership, or any other organization. Here we review &lt;em&gt;Effect of Dexamethasone in Hospitalized Patients with COVID-19 &amp;ndash;&amp;nbsp; Preliminary Report &lt;/em&gt;by Horby &lt;em&gt;et al&lt;/em&gt;, published as a preprint on medRxiv on the 22nd of June, 2020.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Overall, this was a well-conducted, well-designed, practice-changing clinical trial providing the most convincing evidence to date of an efficacious treatment in hospitalised COVID-19 patients. However, there are a number of issues, primarily around the reporting of the trial, that should ideally be resolved prior to final publication. We also urge caution against over-interpreting the estimated subgroup-specific effects based on level of respiratory support, especially the suggestion of harm in the group not on oxygen or mechanical ventilation.&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;</dct:description>
    <dct:accessRights rdf:resource="http://publications.europa.eu/resource/authority/access-right/PUBLIC"/>
    <dct:accessRights>
      <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess">
        <rdfs:label>Open Access</rdfs:label>
      </dct:RightsStatement>
    </dct:accessRights>
    <dct:license rdf:resource="https://creativecommons.org/licenses/by/4.0/legalcode"/>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL rdf:resource="https://doi.org/10.5281/zenodo.3928540"/>
        <dcat:byteSize>630829</dcat:byteSize>
        <dcat:downloadURL rdf:resource="https://zenodo.org/record/3928540/files/Review_20_06_23_Horby(1).pdf"/>
        <dcat:mediaType>application/pdf</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
  </rdf:Description>
</rdf:RDF>
7,391
4,459
views
downloads
All versions This version
Views 7,3917,391
Downloads 4,4594,459
Data volume 2.8 GB2.8 GB
Unique views 6,5526,552
Unique downloads 3,9793,979

Share

Cite as