Journal article Open Access

HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF FUMARIA PARVIFLORA AGAINST CCL4 AND ATT–INDUCED HEPATIC INJURIES IN RATS: A RANDOMIZED CONTROLLED PRECLINICAL TRIAL

Dr.Muthuramu.T1, Abdurohman Mengesha Yessu2, Dr. Mujeeb Ur Rahman3

Fumeria parviflora is (Fumariaceae) is an annual herb found throughout the world. Traditionally it has great significance in various disorders. Hence, the present study was intended to evaluate methanolic plant extract of Fumeria parviflora was studied by CCl4 at the dose of 1ml/kg of body weight in liquid olive oil in the ration of 1:1 and ATT (isoniazid -7.5 mg/kg, rifampicin -10 mg/kg and pyrizinamide -35 mg/kg b.w.) induced models. Acute toxicity study was also studied to evaluate the toxicity. There are no toxicity profile was observed in rats after oral administration of the methanolic plant extract at the dose of 2g/kg body weight. The different doses of 300 mg/kg and 500 mg/kg administered with the extract of Fumeria parviflora there was significant (P < 0.001) reduction in Biochemical parameters with respect to control. Fumaria parviflora demonstrated significant hepatoprotective activity as shown by its ability to control the effect was more at dose of 500 mg/kg for methanol fraction Phytochemical screening of the plant extract revealed the presence of tannins, alkaloids, flavonoids and saponins, and terpenoids. It can be concluded that the hepatoprotective activity elucidated by Fumeria parviflora could be mainly due to the presences of high value class of compound like phenolic group as the major content in the plant.

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