Journal article Open Access
Namrata Rajkumar Singh*, Archana Rajeshwar Sharma, Hrushikesh Vijay Shinde, Kajal Udaiprakash Singh, Mr. Sujit Ubale
The research was aimed to formulate and evaluate floating tablets of Metoprolol Succinate using a combination of natural polymers such as guar gum and xanthan gum as well as a combination of natural and synthetic polymer such as guar gum and HPMC by direct compression and wet granulation method. Metoprolol succinate is a β1- selective adrenergic blocker, used in the management of hypertension, angina pectoris etc. Since the drug has relatively short half-life about 3-7hrs, multiple administration is required every 3-7hrs. The addition of gel-forming polymer, and gas-generating agent was essential to achieve buoyancy. Pre -compression parameters like angle of repose, flow rate, bulk density, tapped density, carr’s index and hausner's ratio of all formulations showed good flow properties. The four batches of floating tablets were formulated with different polymers and were evaluated for hardness, friability, weight variation, drug content uniformity, Invitro buoyancy, swelling Index, Invitro drug release, adhesion retention period. The formulations containing natural polymers have better-sustained release. It releases the drug upto 12hrs and also shows good buoyancy. The formulation containing (Guar gum + Xanthan gum) prepared by wet granulation method was found to be best among all the formulation batches. It shows floating lag time (20sec) and prolonged floating duration upto (12 hrs) which was controlled release characteristic. The maximum release observed at 11 hrs was 98.88%. The result indicate that floating tablet of Metoprolol Succinate containing Guar gum and Xanthun gum prepared by wet granulation method provide better option for controlled release and improve bioavailability.