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El rol de la vitamina D en la infección por SARS-CoV-2

Mayares Villegas, Guillermo


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  "inLanguage": {
    "alternateName": "spa", 
    "@type": "Language", 
    "name": "Spanish"
  }, 
  "description": "<p>Recibido: 01/06/2020.</p>\n\n<p>Aceptado: 09/06/2020.</p>\n\n<p>Publicado: 09/06/2020.</p>\n\n<p>&nbsp;</p>\n\n<p><strong>RESUMEN</strong></p>\n\n<p>En diciembre de 2019, una serie de enfermedades respiratorias agudas at&iacute;picas acontecieron en Wuhan, provincia de Hubei, China. Pronto se descubri&oacute; que el agente causal era un coronavirus, el cual fue denominado 2019-nCov (SARS-CoV-2), y COVID-19 fue el acr&oacute;nimo recomendado por la Organizaci&oacute;n Mundial de la Salud para referirse a la enfermedad.&nbsp; La expansi&oacute;n del virus fue tan r&aacute;pida que para el 30 de enero del 2020, el Director General de la Organizaci&oacute;n Mundial de la Salud, el Dr. Tedros Adhanom Ghebreyesus, declar&oacute; el brote como una emergencia de salud p&uacute;blica de importancia internacional.</p>\n\n<p>A falta de una vacuna para prevenir el COVID-19, y debido a la cr&iacute;tica situaci&oacute;n que nos acontece por la agresividad de la pandemia, se requiere de manera urgente una medida terap&eacute;utica que disminuya el riesgo de infecci&oacute;n o el agravamiento de la enfermedad. En el presente escrito, se discute la importancia de la suplementaci&oacute;n de vitamina D como una herramienta de protecci&oacute;n para mantener un adecuado funcionamiento del sistema inmune. Se plantean 3 posibles mecanismos por los cuales la vitamina D puede ejercer un efecto protector ante el SARS-CoV-2: respuesta antimicrobiana a trav&eacute;s de la inducci&oacute;n de catelicidinas y defensinas, respuesta antiinflamatoria al regular negativamente la producci&oacute;n de citocinas proinflamatorias (IL-1, IL-6, IL-23, TNF-&alpha;, INF), y la inducci&oacute;n de la autofagia al regular prote&iacute;nas relacionadas con la autofagia (AMPK, mTOR, Beclin1/PI3K, catelicidina). Estos mecanismos podr&iacute;an disminuir la proliferaci&oacute;n de dicho virus y reducir el da&ntilde;o tisular generado por la inflamaci&oacute;n.</p>\n\n<p>&nbsp;</p>\n\n<p>&nbsp;</p>\n\n<p><strong>ABSTRACT</strong></p>\n\n<p>In December 2019, a series of atypical acute respiratory illnesses occurred in Wuhan, Hubei Province, China. The causative agent was soon discovered to be a coronavirus, which was dubbed 2019-nCov (SARS-CoV-2), and COVID-19 was the acronym recommended by the World Health Organization to refer to the disease. The spread of the virus was so rapid that by January 30, 2020, the Director-General of the World Health Organization, Dr. Tedros Adhanom Ghebreyesus, declared the outbreak to be a public health emergency of international importance.</p>\n\n<p>In the absence of a vaccine to prevent COVID-19, and due to the critical situation that is happening to us due to the aggressiveness of the pandemic, a therapeutic measure is urgently required to reduce the risk of infection or the worsening of the disease. In this paper, the importance of vitamin D supplementation as a protection tool to maintain proper functioning of the immune system is discussed. 3 possible mechanisms are proposed by which vitamin D can exert a protective effect against SARS-CoV-2: antimicrobial response through the induction of cathelicidins and defensins, anti-inflammatory response by negatively regulating the production of proinflammatory cytokines (IL-1, IL-6, IL-23, TNF-&alpha;, INF), and autophagy induction by regulating autophagy-related proteins (AMPK, mTOR, Beclin1 / PI3K, cathelicidin). These mechanisms could decrease the proliferation of said virus and reduce the tissue damage generated by inflammation.</p>\n\n<p>&nbsp;</p>\n\n<p>&nbsp;</p>\n\n<p><strong>2020 &copy; Revista Cadena de Cerebros</strong></p>\n\n<p><strong><a href=\"https://www.cadenadecerebros.com\">www.cadenadecerebros.com</a></strong></p>\n\n<p><strong>e-ISSN: 2448-8178.</strong></p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Licenciatura en Medicina, Universidad Aut\u00f3noma Metropolitana. Ciudad de M\u00e9xico, M\u00e9xico.", 
      "@type": "Person", 
      "name": "Mayares Villegas, Guillermo"
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  ], 
  "headline": "El rol de la vitamina D en la infecci\u00f3n por SARS-CoV-2", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2020-06-09", 
  "url": "https://zenodo.org/record/3903950", 
  "keywords": [
    "Coronavirus", 
    "Vitamina D", 
    "Suplementaci\u00f3n", 
    "Prevenci\u00f3n", 
    "Autofagia", 
    "Vitamin D", 
    "Supplementation", 
    "Prevention", 
    "Autophagy"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.3903950", 
  "@id": "https://doi.org/10.5281/zenodo.3903950", 
  "@type": "ScholarlyArticle", 
  "name": "El rol de la vitamina D en la infecci\u00f3n por SARS-CoV-2"
}
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