Journal article Open Access

El rol de la vitamina D en la infección por SARS-CoV-2

Mayares Villegas, Guillermo


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        <foaf:name>Mayares Villegas, Guillermo</foaf:name>
        <foaf:givenName>Guillermo</foaf:givenName>
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            <foaf:name>Licenciatura en Medicina, Universidad Autónoma Metropolitana. Ciudad de México, México.</foaf:name>
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    <dct:title>El rol de la vitamina D en la infección por SARS-CoV-2</dct:title>
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    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2020</dct:issued>
    <dcat:keyword>Coronavirus</dcat:keyword>
    <dcat:keyword>Vitamina D</dcat:keyword>
    <dcat:keyword>Suplementación</dcat:keyword>
    <dcat:keyword>Prevención</dcat:keyword>
    <dcat:keyword>Autofagia</dcat:keyword>
    <dcat:keyword>Vitamin D</dcat:keyword>
    <dcat:keyword>Supplementation</dcat:keyword>
    <dcat:keyword>Prevention</dcat:keyword>
    <dcat:keyword>Autophagy</dcat:keyword>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2020-06-09</dct:issued>
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    <dct:description>&lt;p&gt;Recibido: 01/06/2020.&lt;/p&gt; &lt;p&gt;Aceptado: 09/06/2020.&lt;/p&gt; &lt;p&gt;Publicado: 09/06/2020.&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt; &lt;p&gt;&lt;strong&gt;RESUMEN&lt;/strong&gt;&lt;/p&gt; &lt;p&gt;En diciembre de 2019, una serie de enfermedades respiratorias agudas at&amp;iacute;picas acontecieron en Wuhan, provincia de Hubei, China. Pronto se descubri&amp;oacute; que el agente causal era un coronavirus, el cual fue denominado 2019-nCov (SARS-CoV-2), y COVID-19 fue el acr&amp;oacute;nimo recomendado por la Organizaci&amp;oacute;n Mundial de la Salud para referirse a la enfermedad.&amp;nbsp; La expansi&amp;oacute;n del virus fue tan r&amp;aacute;pida que para el 30 de enero del 2020, el Director General de la Organizaci&amp;oacute;n Mundial de la Salud, el Dr. Tedros Adhanom Ghebreyesus, declar&amp;oacute; el brote como una emergencia de salud p&amp;uacute;blica de importancia internacional.&lt;/p&gt; &lt;p&gt;A falta de una vacuna para prevenir el COVID-19, y debido a la cr&amp;iacute;tica situaci&amp;oacute;n que nos acontece por la agresividad de la pandemia, se requiere de manera urgente una medida terap&amp;eacute;utica que disminuya el riesgo de infecci&amp;oacute;n o el agravamiento de la enfermedad. En el presente escrito, se discute la importancia de la suplementaci&amp;oacute;n de vitamina D como una herramienta de protecci&amp;oacute;n para mantener un adecuado funcionamiento del sistema inmune. Se plantean 3 posibles mecanismos por los cuales la vitamina D puede ejercer un efecto protector ante el SARS-CoV-2: respuesta antimicrobiana a trav&amp;eacute;s de la inducci&amp;oacute;n de catelicidinas y defensinas, respuesta antiinflamatoria al regular negativamente la producci&amp;oacute;n de citocinas proinflamatorias (IL-1, IL-6, IL-23, TNF-&amp;alpha;, INF), y la inducci&amp;oacute;n de la autofagia al regular prote&amp;iacute;nas relacionadas con la autofagia (AMPK, mTOR, Beclin1/PI3K, catelicidina). Estos mecanismos podr&amp;iacute;an disminuir la proliferaci&amp;oacute;n de dicho virus y reducir el da&amp;ntilde;o tisular generado por la inflamaci&amp;oacute;n.&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt; &lt;p&gt;&lt;strong&gt;ABSTRACT&lt;/strong&gt;&lt;/p&gt; &lt;p&gt;In December 2019, a series of atypical acute respiratory illnesses occurred in Wuhan, Hubei Province, China. The causative agent was soon discovered to be a coronavirus, which was dubbed 2019-nCov (SARS-CoV-2), and COVID-19 was the acronym recommended by the World Health Organization to refer to the disease. The spread of the virus was so rapid that by January 30, 2020, the Director-General of the World Health Organization, Dr. Tedros Adhanom Ghebreyesus, declared the outbreak to be a public health emergency of international importance.&lt;/p&gt; &lt;p&gt;In the absence of a vaccine to prevent COVID-19, and due to the critical situation that is happening to us due to the aggressiveness of the pandemic, a therapeutic measure is urgently required to reduce the risk of infection or the worsening of the disease. In this paper, the importance of vitamin D supplementation as a protection tool to maintain proper functioning of the immune system is discussed. 3 possible mechanisms are proposed by which vitamin D can exert a protective effect against SARS-CoV-2: antimicrobial response through the induction of cathelicidins and defensins, anti-inflammatory response by negatively regulating the production of proinflammatory cytokines (IL-1, IL-6, IL-23, TNF-&amp;alpha;, INF), and autophagy induction by regulating autophagy-related proteins (AMPK, mTOR, Beclin1 / PI3K, cathelicidin). These mechanisms could decrease the proliferation of said virus and reduce the tissue damage generated by inflammation.&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt; &lt;p&gt;&lt;strong&gt;2020 &amp;copy; Revista Cadena de Cerebros&lt;/strong&gt;&lt;/p&gt; &lt;p&gt;&lt;strong&gt;&lt;a href="https://www.cadenadecerebros.com"&gt;www.cadenadecerebros.com&lt;/a&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p&gt;&lt;strong&gt;e-ISSN: 2448-8178.&lt;/strong&gt;&lt;/p&gt;</dct:description>
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