December 31, 2019 Journal article Open Access

Jiménez-Arellanes, María Adelina

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  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Mastron J, Siveen K, Sethi G, Bishayee A. Silymarin and hepatocellular carcinoma: A systematic, comprehensive and crtical review. Anti-cancer Drugs. 2015; 26(5): 475-86. DOI: 10.1097/cad.0000000000000211</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Kumar T, Larokar YK, Iyer SK, Kumar A, Tripathi DK. Phytochemistry and Pharmacological Activities of Silybum marianum: A Review. Int J Pharm Phytopharm Res. 8677; 7(9): 784 -33. Disponible en: https://www.academia.edu/2470494/Phytochemistry_and_Pharmacological_Activities_of_Silybum_marianum_A_Review</subfield>
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  <datafield tag="999" ind1="C" ind2="5">
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Ferenci P. Silymarin in the treatment of liver diseases: What is the clinical evidence? Clin Liv Dis (Hoboken). 2016; 7(1): 8-10. DOI: 10.1002/cld.522</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res. 2006; 124(5): 491-504. Disponible en: http://www.ijmr.org.in/article.asp?issn=09715916;year=2013;volume=137;issue=2;spage=423;epage=436;aulast=Pradhan;type=0</subfield>
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  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS. Flavonoid, Silibinin, Inhibits Proliferation and Promotes Cell-Cycle Arrest of Human Colon Cancer. J Surg Res. 2007; 143(1), 58-65. DOI: 10.1016/j.jss.2007.03.080</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Jahan S, Khan M, Imran S, Sair M. The hepatoprotective role of Silymarin in isoniazid induced liver damage of rabbits. J Pak Med Assoc. 2015; 65(6): 620-2. Disponible en: https://jpma.org.pk/article-details/7375?article_id=7375</subfield>
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  <datafield tag="999" ind1="C" ind2="5">
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Bektur NE, Sahin E, Baycu C, Unver G. Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice. Toxicol Ind Health. 2013; 32(4): 589-600. DOI: 10.1177/0748233713502841</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Pari L, Kumar NA. Hepatoprotective Activity of Moringa oleifera on Antitubercular Drug-Induced Liver Damage in Rats. J Med Food. 2002; 5(3): 171-7. DOI: 10.1089/10966200260398206</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Domitrović R, Rashed K, Cvijanović O, Vladimir-Knežević S, Škoda M, Višnić A. Myricitrin exhibits antioxidant, antiinflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. Chem Biol Interact. 2015; 230: 21-9. DOI: 10.1016/j.cbi.2015.01.030</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Kim SH, Oh DS, Oh JY, Son TG, Yuk DY, Jung YS. Silymarin Prevents Restraint Stress-Induced Acute Liver Injury by Ameliorating Oxidative Stress and Reducing Inflammatory Response. Molecules. 2016; 21(4): 443. DOI: 10.3390/molecules21040443</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Chen IS, Chen YC, Chou CH, Chuang RF, Sheen LY, Chiu CH. Hepatoprotection of silymarin against thioacetamideinduced chronic liver fibrosis. J Sci Food Agric. 2012; 92(7): 1441-7. DOI: 10.1002/jsfa.4723</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Jaswal A, Sinha N, Bhadauria M, Shrivastava S, Shukla S. Therapeutic potential of thymoquinone against antituberculosis drugs induced liver damage. Environ Toxicol Pharmacol. 2013; 36(3): 779-86. DOI: 10.1016/j.etap.2013.07.010</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Rao CV, Rawat A, Singh AP, Singh A, Verma N. Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia (L.) Mill roots against antitubercular drugs induced hepatotoxicity in experimental models. Asian Pac J Trop Med. 2012; 5(4): 283-8. DOI: 10.1016/s1995-7645(12)60040-6</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Sozmen M, Devrim AK, Tunca R, Bayezit M, Dag S, Essiz D. Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice. J Vet Sci. 2014; 15(1): 51-60. DOI: 10.4142/jvs.2014.15.1.51</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Amin KA, Ahmed RR, Hozayen WG, Antar A. Renoprotective and Antioxidant Effects of Silymarin and Propolis on Diclofenac Sodium - Induced Renal Toxicity in Rats. Int J Pure Appl Biosci. 2017; 5(2): 31-42. DOI: 10.18782/23207051.2421</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Naik M, Chakraborty M, Ahmed R, Hamza S, Afsal M. Investigation of nefroprotective effect of silymarin against methotrexate and ifosfamide induced toxicity in rats. Int J Pharm Sci Res. 2015; 6(1): 174-9. Disponible en: https://www.semanticscholar.org/paper/INVESTIGATION-OFNEPFROPROTECTIVE-EFFECT-OF-AGAINST-Naik-Chakraborty/00d48d4f16d7cf6997b40c6f7ef4a667fc84b0af</subfield>
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Shahbazi F, Dashti-Khavidaki S, Khalili H, Lessan-Pezeshki M. Potential renoprotective effects of silymarin against nephrotoxic drugs: A review of literature. J Pharm Pharmaceut Sci. 2012; 15(1): 112-23. DOI: 10.18433/J3F88S</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Gaedeke J, Fels LM, Bokemeyer C, Mengs U, Stolte H, Lentzen H. Cisplatin nephrotoxicity and protection by silibinin. Nephrol Dial Transplant. 1996; 11(1): 55-62.</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Bailón D. Evaluación del efecto hepatoprotector de Rosmarinus officinalis y la mezcla de triterpenos contra el daño inducido por fármacos antituberculosos. Tesis Maestría. Instituto Politécnico Nacional. 2016.</subfield>
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  <datafield tag="999" ind1="C" ind2="5">
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Jashitha M, Chakraborty M, Kamath JV. Effect of quercetin on hepatoprotective activity of silymarin against thioacetamide intoxicated rats. Int Res J Pharm. 2013; 4(7): 138-40. DOI: 10.7897/2230-8407.04730</subfield>
  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Javed S, Ahsan W, Kohli K. Pharmacological influences of natural products as bioenhancers of silymarin against carbon tetrachloride-induced hepatotoxicity in rats. Clin Phytosci 2018; 4(1): 18. DOI: 10.1186/s40816-018-0079-6</subfield>
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  </datafield>
  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Ghosh A, Ghosh T, Jain S. Silymarin-A review on the pharmacodynamics and bioavailability enhancement approaches. J Pharm Sci Techn. 2010; 2(10): 348-55. Disponible en: http://www.onlinepharmacytech.info/docs/vol2issue10/ JPST10-02-10-04.pdf</subfield>
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  <datafield tag="999" ind1="C" ind2="5">
    <subfield code="x">Bahmani M, Shirzad H, Rafieian S, Rafieian-Kopaei M. Silybum marianum: Beyond Hepatoprotection. J Evid Based Complementary Altern Med. 2015; 20(4): 292-301. DOI: 10.1177/2156587215571116</subfield>
  </datafield>
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    <subfield code="a">&lt;p&gt;&lt;strong&gt;RESUMEN&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;El h&amp;iacute;gado es el encargado de la homeostasis y de metabolizar diversas sustancias (end&amp;oacute;genas y ex&amp;oacute;genas, incluyendo f&amp;aacute;rmacos), las cuales al metabolizarse generan metabolitos m&amp;aacute;s t&amp;oacute;xicos y/o reactivos; por esto el h&amp;iacute;gado es m&amp;aacute;s susceptible de sufrir alg&amp;uacute;n da&amp;ntilde;o como cirrosis, esteatosis y/o hasta hepatocarcinoma. El ser humano ha empleado diversas plantas medicinales (PM) desde tiempos ancestrales para tratar sus padecimientos, enfermedades y dolencias; entre ellas esta Sylibum marianum. Planta utilizada en el tratamiento de ictericia u otras enfermedades biliares; as&amp;iacute; como, en terapia de apoyo en la intoxicaci&amp;oacute;n por hongos y en el tratamiento de diversas enfermedades hep&amp;aacute;ticas. A partir de esta especie medicinal se obtiene la silimarina (mezcla de flavonoides), esta sustancia tiene importante efecto antioxidante, tambi&amp;eacute;n tiene diversas actividades biol&amp;oacute;gicas como hepatoprotector. Esta actividad se ha demostrado mediante diversos estudios precl&amp;iacute;nicos y cl&amp;iacute;nicos.&lt;/p&gt;

&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;ABSTRACT&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;The liver is in charge of homeostasis and of metabolizing various substances (endogenous and exogenous, including drugs), many of which, when metabolized, generate more toxic and/or reactive metabolites, for this reason, the liver is more susceptible to suffer some damage such as cirrhosis, steatosis and/or even hepatocarcinoma. The humanity has been used several medicinal plants (PM) since ancestral times to treat their ailments, diseases and ailments; among them is Sylibum marianum, that has been used in the treatment of jaundice or other biliary diseases; as well as, in supportive therapy in fungal poisoning and in the treatment of some liver diseases. From this medicinal plant has been obtained sylimarin (flavonoids mixture), this substance has significative antioxidant effect, also has some biological activities such as hepatoprotective. This activity has been demonstrated by preclinical and clinical trials.&lt;/p&gt;</subfield>
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    <subfield code="n">doi</subfield>
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    <subfield code="a">10.5281/zenodo.3903936</subfield>
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  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.5281/zenodo.3903937</subfield>
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  </datafield>
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