December 31, 2019 Journal article Open Access

Jiménez-Arellanes, María Adelina

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{
  "inLanguage": {
    "alternateName": "spa", 
    "@type": "Language", 
    "name": "Spanish"
  }, 
  "description": "<p><strong>RESUMEN</strong></p>\n\n<p>El h&iacute;gado es el encargado de la homeostasis y de metabolizar diversas sustancias (end&oacute;genas y ex&oacute;genas, incluyendo f&aacute;rmacos), las cuales al metabolizarse generan metabolitos m&aacute;s t&oacute;xicos y/o reactivos; por esto el h&iacute;gado es m&aacute;s susceptible de sufrir alg&uacute;n da&ntilde;o como cirrosis, esteatosis y/o hasta hepatocarcinoma. El ser humano ha empleado diversas plantas medicinales (PM) desde tiempos ancestrales para tratar sus padecimientos, enfermedades y dolencias; entre ellas esta Sylibum marianum. Planta utilizada en el tratamiento de ictericia u otras enfermedades biliares; as&iacute; como, en terapia de apoyo en la intoxicaci&oacute;n por hongos y en el tratamiento de diversas enfermedades hep&aacute;ticas. A partir de esta especie medicinal se obtiene la silimarina (mezcla de flavonoides), esta sustancia tiene importante efecto antioxidante, tambi&eacute;n tiene diversas actividades biol&oacute;gicas como hepatoprotector. Esta actividad se ha demostrado mediante diversos estudios precl&iacute;nicos y cl&iacute;nicos.</p>\n\n<p>&nbsp;</p>\n\n<p>&nbsp;</p>\n\n<p><strong>ABSTRACT</strong></p>\n\n<p>The liver is in charge of homeostasis and of metabolizing various substances (endogenous and exogenous, including drugs), many of which, when metabolized, generate more toxic and/or reactive metabolites, for this reason, the liver is more susceptible to suffer some damage such as cirrhosis, steatosis and/or even hepatocarcinoma. The humanity has been used several medicinal plants (PM) since ancestral times to treat their ailments, diseases and ailments; among them is Sylibum marianum, that has been used in the treatment of jaundice or other biliary diseases; as well as, in supportive therapy in fungal poisoning and in the treatment of some liver diseases. From this medicinal plant has been obtained sylimarin (flavonoids mixture), this substance has significative antioxidant effect, also has some biological activities such as hepatoprotective. This activity has been demonstrated by preclinical and clinical trials.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Unidad de Investigaci\u00f3n M\u00e9dica en Farmacolog\u00eda, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Ciudad de M\u00e9xico, M\u00e9xico.", 
      "@id": "https://orcid.org/0000-0002-9379-5601", 
      "@type": "Person", 
      "name": "Jim\u00e9nez-Arellanes, Mar\u00eda Adelina"
    }
  ], 
  "headline": "Silimarina como potencial agente hepatoprotector", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2019-12-31", 
  "url": "https://zenodo.org/record/3903937", 
  "keywords": [
    "Silimarina", 
    "hepatotoxicidad", 
    "silibina", 
    "hepatoprotector", 
    "nefroprotector", 
    "Silymarin", 
    "hepatotoxicity", 
    "silibin", 
    "hepatoprotective", 
    "nephroprotective"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.3903937", 
  "@id": "https://doi.org/10.5281/zenodo.3903937", 
  "@type": "ScholarlyArticle", 
  "name": "Silimarina como potencial agente hepatoprotector"
}