Journal article Open Access

Silimarina como potencial agente hepatoprotector

Jiménez-Arellanes, María Adelina

JSON Export

  "files": [
      "links": {
        "self": ""
      "checksum": "md5:c7b89a8af2f2a4e3da9d62cef5350161", 
      "bucket": "f04ba5c8-e4f2-46ac-8e75-c73016ec051b", 
      "key": "ART-RE-32-02.pdf", 
      "type": "pdf", 
      "size": 991744
  "owners": [
  "doi": "10.5281/zenodo.3903937", 
  "stats": {
    "version_unique_downloads": 394.0, 
    "unique_views": 270.0, 
    "views": 284.0, 
    "version_views": 284.0, 
    "unique_downloads": 394.0, 
    "version_unique_views": 270.0, 
    "volume": 411573760.0, 
    "version_downloads": 415.0, 
    "downloads": 415.0, 
    "version_volume": 411573760.0
  "links": {
    "doi": "", 
    "conceptdoi": "", 
    "bucket": "", 
    "conceptbadge": "", 
    "html": "", 
    "latest_html": "", 
    "badge": "", 
    "latest": ""
  "conceptdoi": "10.5281/zenodo.3903936", 
  "created": "2020-06-23T01:19:55.502948+00:00", 
  "updated": "2020-08-08T20:43:31.485242+00:00", 
  "conceptrecid": "3903936", 
  "revision": 5, 
  "id": 3903937, 
  "metadata": {
    "access_right_category": "success", 
    "doi": "10.5281/zenodo.3903937", 
    "description": "<p><strong>RESUMEN</strong></p>\n\n<p>El h&iacute;gado es el encargado de la homeostasis y de metabolizar diversas sustancias (end&oacute;genas y ex&oacute;genas, incluyendo f&aacute;rmacos), las cuales al metabolizarse generan metabolitos m&aacute;s t&oacute;xicos y/o reactivos; por esto el h&iacute;gado es m&aacute;s susceptible de sufrir alg&uacute;n da&ntilde;o como cirrosis, esteatosis y/o hasta hepatocarcinoma. El ser humano ha empleado diversas plantas medicinales (PM) desde tiempos ancestrales para tratar sus padecimientos, enfermedades y dolencias; entre ellas esta Sylibum marianum. Planta utilizada en el tratamiento de ictericia u otras enfermedades biliares; as&iacute; como, en terapia de apoyo en la intoxicaci&oacute;n por hongos y en el tratamiento de diversas enfermedades hep&aacute;ticas. A partir de esta especie medicinal se obtiene la silimarina (mezcla de flavonoides), esta sustancia tiene importante efecto antioxidante, tambi&eacute;n tiene diversas actividades biol&oacute;gicas como hepatoprotector. Esta actividad se ha demostrado mediante diversos estudios precl&iacute;nicos y cl&iacute;nicos.</p>\n\n<p>&nbsp;</p>\n\n<p>&nbsp;</p>\n\n<p><strong>ABSTRACT</strong></p>\n\n<p>The liver is in charge of homeostasis and of metabolizing various substances (endogenous and exogenous, including drugs), many of which, when metabolized, generate more toxic and/or reactive metabolites, for this reason, the liver is more susceptible to suffer some damage such as cirrhosis, steatosis and/or even hepatocarcinoma. The humanity has been used several medicinal plants (PM) since ancestral times to treat their ailments, diseases and ailments; among them is Sylibum marianum, that has been used in the treatment of jaundice or other biliary diseases; as well as, in supportive therapy in fungal poisoning and in the treatment of some liver diseases. From this medicinal plant has been obtained sylimarin (flavonoids mixture), this substance has significative antioxidant effect, also has some biological activities such as hepatoprotective. This activity has been demonstrated by preclinical and clinical trials.</p>", 
    "language": "spa", 
    "title": "Silimarina como potencial agente hepatoprotector", 
    "license": {
      "id": "CC-BY-4.0"
    "journal": {
      "volume": "3", 
      "issue": "2", 
      "pages": "60-70", 
      "title": "Revista Cadena de Cerebros"
    "relations": {
      "version": [
          "count": 1, 
          "index": 0, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "3903936"
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "3903937"
    "communities": [
        "id": "cadenadecerebros"
        "id": "medicina-enfermeria-odontologia-latinoamerica"
    "references": [
      "Vargas-Mendoza N, Madrigal-Santill\u00e1n E, MoralesGonz\u00e1lez \u00c1, Esquivel-Soto J, Esquivel-Chirino C, Garc\u00edaLuna y Gonz\u00e1lez-Rubio M, et al. Hepatoprotective effect of silymarin. World J Hepatol. 2014; 6(3): 144-9. DOI: 10.4254/wjh.v6.i3.144", 
      "Hoekstra LT, de Graaf W, Nibourg GAA, Heger M, Bennink RJ, Stieger B, et al. Physiological and Biochemical Basis of Clinical Liver Function Tests. Annals Surg. 2013; 257(1): 2736. DOI: 10.1097/sla.0b013e31825d5d47", 
      "Bertuccio P, Turati F, Carioli G, Rodriguez T, La Vecchia C, Malvezzi M, et al. Global Trends and Predictions in Hepatocellular Carcinoma Mortality. J Hepatol. 2017; 67(2): 302 -9. DOI: 10.1016/j.jhep.2017.03.011", 
      "Global Hepatitis Report 2017. 1a Edici\u00f3n. Geneva: World Health Organization; 2017. Disponible en:", 
      "Rowe IA. Lessons from Epidemiology: The Burden of Liver Disease. Dig Dis. 2017; 35(4): 304-9. DOI: 10.1159/000456580", 
      "Jim\u00e9nez-Arellanes MA, Guti\u00e9rrez-Rebolledo GA, MeckesFischer M, Le\u00f3n-D\u00edaz R. Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review. Asian Pac J Trop Med. 2016; 9(12): 1141-9. DOI: 10.1016/j.apjtm.2016.10.010", 
      "Damian D. Efecto hepatoprotector del extracto org\u00e1nico de las partes a\u00e9reas de Cnidoscolus chayamansa. Tesis de Maestr\u00eda. Tecnol\u00f3gico de Estudios Superiores de Ecatepec. 2018.", 
      "Salwe KJ, Mirunalini R, Mano J, Manimekalai K. Hepatoprotective and antioxidant activity of Murraya Koenigii leaves extract against paracetamol induced hepatotoxicity in Rats. Int J Bas Clin Pharmacol. 2017; 6(6): 1274-81. DOI: 10.18203/2319-2003.ijbcp20172044", 
      "Asadi-Samani M, Kafash-Farkhad N, Azimi N, Fasihi A, Alinia-Ahandani E, Rafieian-Kopaei M. Medicinal plants with hepatoprotective activity in Iranian folk medicine. Asian Pac J Trop Biomed. 2015; 5(2): 146-57. DOI: 10.1016/S2221-1691(15)30159-3", 
      "Bail\u00f3n-Mart\u00ednez D, Jim\u00e9nez-Arellanes MA. Efecto hepatoprotector de compuestos naturales, productos biol\u00f3gicos y extractos de plantas medicinales contra el da\u00f1o provocado por f\u00e1rmacos antituberculosos (Parte II). Rev Mex Cienc Farm. 2018; 49(3): 1-31.", 
      "Quezada SM, Briscoe J, Cross RK. Complementary and Alternative Medicine. Inflamm Bowel Dis. 2016; 22(6): 1523-30. DOI: 10.1097/MIB.0000000000000761", 
      "Azwanida NN. A Review on the Extraction Methods Use in Medicinal Plants, Principle, Strength and Limitation. Med Arom Plants. 2015; 4(3): 1000196. DOI: 10.4172/21670412.1000196", 
      "Comelli MC, Mengs U, Schneider C, Prosdocimi M. Toward the Definition of the Mechanism of Action of Silymarin: Activities Related to Cellular Protection from Toxic Damage Induced by Chemotherapy. Integr Cancer Ther. 2007; 6 (2): 120-9. DOI: 10.1177/1534735407302349", 
      "Mastron J, Siveen K, Sethi G, Bishayee A. Silymarin and hepatocellular carcinoma: A systematic, comprehensive and crtical review. Anti-cancer Drugs. 2015; 26(5): 475-86. DOI: 10.1097/cad.0000000000000211", 
      "Kumar T, Larokar YK, Iyer SK, Kumar A, Tripathi DK. Phytochemistry and Pharmacological Activities of Silybum marianum: A Review. Int J Pharm Phytopharm Res. 8677; 7(9): 784 -33. Disponible en:", 
      "Hellerbrand C, Schattenberg JM, Peterburs P, Lechner A, Brignoli R. The potential of silymarin for the treatment of hepatic disorders. Clin Phytosci. 2016; 2(7): 1-14. DOI: 10.1186/s40816-016-0019-2", 
      "Kawaguchi-Suzuki M, Frye RF, Zhu HJ, Brinda BJ, Chavin KD, Bernstein HJ, et al. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P894 Activity. Drug Metab Dispos. 2014; 42(10): 1611-6. DOI: 10.1124/dmd.114.057232", 
      "Ferenci P. Silymarin in the treatment of liver diseases: What is the clinical evidence? Clin Liv Dis (Hoboken). 2016; 7(1): 8-10. DOI: 10.1002/cld.522", 
      "Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res. 2006; 124(5): 491-504. Disponible en:;year=2013;volume=137;issue=2;spage=423;epage=436;aulast=Pradhan;type=0", 
      "Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS. Flavonoid, Silibinin, Inhibits Proliferation and Promotes Cell-Cycle Arrest of Human Colon Cancer. J Surg Res. 2007; 143(1), 58-65. DOI: 10.1016/j.jss.2007.03.080", 
      "Jahan S, Khan M, Imran S, Sair M. The hepatoprotective role of Silymarin in isoniazid induced liver damage of rabbits. J Pak Med Assoc. 2015; 65(6): 620-2. Disponible en:", 
      "Panchabhai TS, Ambarkhane SV, Joshi AS, Samant BD, Rege NN.  Protective Effect of Tinospora cordifolia, Phyllanthus emblica and Their Combination Against Antitubercular Drugs Induced Hepatic Damage: An Experimental Study. Phytother Res. 2008; 22(5): 646-50. DOI: 10.1002/ptr.2356", 
      "Clichici S, Olteanu D, Nagy A, Oros A, Filip A, Mircea PA. Silymarin Inhibits the Progression of Fibrosis in the Early Stages of Liver Injury in CCl4-Treated Rats. J Med Food. 2015; 18(3): 290-8. DOI: 10.1089/jmf.2013.0179", 
      "Hermenean A, Stan M, Ardelean A, Pilat L, Mihali CV, Popescu C, et al. Antioxidant and hepatoprotective activity of milk thistle (Silybum marianum L. Gaertn.) seed oil. Open Life Sci. 2015; 10(1): 225-36. DOI: 10.1515/biol-2015-0017", 
      "Bektur NE, Sahin E, Baycu C, Unver G. Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice. Toxicol Ind Health. 2013; 32(4): 589-600. DOI: 10.1177/0748233713502841", 
      "Pari L, Kumar NA. Hepatoprotective Activity of Moringa oleifera on Antitubercular Drug-Induced Liver Damage in Rats. J Med Food. 2002; 5(3): 171-7. DOI: 10.1089/10966200260398206", 
      "Domitrovi\u0107 R, Rashed K, Cvijanovi\u0107 O, Vladimir-Kne\u017eevi\u0107 S, \u0160koda M, Vi\u0161ni\u0107 A. Myricitrin exhibits antioxidant, antiinflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. Chem Biol Interact. 2015; 230: 21-9. DOI: 10.1016/j.cbi.2015.01.030", 
      "Kim SH, Oh DS, Oh JY, Son TG, Yuk DY, Jung YS. Silymarin Prevents Restraint Stress-Induced Acute Liver Injury by Ameliorating Oxidative Stress and Reducing Inflammatory Response. Molecules. 2016; 21(4): 443. DOI: 10.3390/molecules21040443", 
      "Chen IS, Chen YC, Chou CH, Chuang RF, Sheen LY, Chiu CH. Hepatoprotection of silymarin against thioacetamideinduced chronic liver fibrosis. J Sci Food Agric. 2012; 92(7): 1441-7. DOI: 10.1002/jsfa.4723", 
      "Jaswal A, Sinha N, Bhadauria M, Shrivastava S, Shukla S. Therapeutic potential of thymoquinone against antituberculosis drugs induced liver damage. Environ Toxicol Pharmacol. 2013; 36(3): 779-86. DOI: 10.1016/j.etap.2013.07.010", 
      "Rao CV, Rawat A, Singh AP, Singh A, Verma N. Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia (L.) Mill roots against antitubercular drugs induced hepatotoxicity in experimental models. Asian Pac J Trop Med. 2012; 5(4): 283-8. DOI: 10.1016/s1995-7645(12)60040-6", 
      "Sozmen M, Devrim AK, Tunca R, Bayezit M, Dag S, Essiz D. Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice. J Vet Sci. 2014; 15(1): 51-60. DOI: 10.4142/jvs.2014.15.1.51", 
      "Amin KA, Ahmed RR, Hozayen WG, Antar A. Renoprotective and Antioxidant Effects of Silymarin and Propolis on Diclofenac Sodium - Induced Renal Toxicity in Rats. Int J Pure Appl Biosci. 2017; 5(2): 31-42. DOI: 10.18782/23207051.2421", 
      "Naik M, Chakraborty M, Ahmed R, Hamza S, Afsal M. Investigation of nefroprotective effect of silymarin against methotrexate and ifosfamide induced toxicity in rats. Int J Pharm Sci Res. 2015; 6(1): 174-9. Disponible en:", 
      "Gopi K, Reddy A, Jyothi K, Kumar B. Acetaminopheninduced Hepato- and Nephrotoxicity and Amelioration by Silymarin and Terminalia chebula in Rats. Toxicol Int. 2010; 17(2): 64-6. DOI: 10.4103/0971-6580.72672", 
      "Shahbazi F, Dashti-Khavidaki S, Khalili H, Lessan-Pezeshki M. Potential renoprotective effects of silymarin against nephrotoxic drugs: A review of literature. J Pharm Pharmaceut Sci. 2012; 15(1): 112-23. DOI: 10.18433/J3F88S", 
      "Gaedeke J, Fels LM, Bokemeyer C, Mengs U, Stolte H, Lentzen H. Cisplatin nephrotoxicity and protection by silibinin. Nephrol Dial Transplant. 1996; 11(1): 55-62.", 
      "Bail\u00f3n D. Evaluaci\u00f3n del efecto hepatoprotector de Rosmarinus officinalis y la mezcla de triterpenos contra el da\u00f1o inducido por f\u00e1rmacos antituberculosos. Tesis Maestr\u00eda. Instituto Polit\u00e9cnico Nacional. 2016.", 
      "Rasool M, Iqbal J, Malik A, Ramzan HS, Qureshi MS, Asif M, et al. Hepatoprotective Effects of Silybum marianum (Silymarin) and Glycyrrhiza glabra (Glycyrrhizin) in Combination: A Possible Synergy. Evid Based Complement Alternat Med. 2014; 2014: 641597. DOI: 10.1155/2014/641597", 
      "Kim SH, Cheon HJ, Yun N, Oh ST, Shin E, Shim KS, et al. Protective Effect of a Mixture of Aloe vera and Silybum marianum Against Carbon Tetrachloride\u2013Induced Acute Hepatotoxicity and Liver Fibrosis. J Pharmacol Sci. 2009; 109(1): 119-27. DOI: 10.1254/jphs.08189fp", 
      "Jashitha M, Chakraborty M, Kamath JV. Effect of quercetin on hepatoprotective activity of silymarin against thioacetamide intoxicated rats. Int Res J Pharm. 2013; 4(7): 138-40. DOI: 10.7897/2230-8407.04730", 
      "Giacomelli S, Gallo D, Apollonio P, Ferlini C, Distefano M, Morazzoni P, et al. Silybin and its bioavailable phospholipid complex (IdB 1016) potentiate in vitro and in vivo the activity of cisplatin. Life Sci. 2002; 70(12): 1447-59. DOI: 10.1016/s0024-3205(01)01511-9", 
      "Javed S, Ahsan W, Kohli K. Pharmacological influences of natural products as bioenhancers of silymarin against carbon tetrachloride-induced hepatotoxicity in rats. Clin Phytosci 2018; 4(1): 18. DOI: 10.1186/s40816-018-0079-6", 
      "Nada SA, Gowife AMH, El-Denshary EES, Salama AA, Khali MG, Ahmed KA. Protective Effect of Grape Seed Extract and/or Silymarin Against Thioacetamide-induced Hepatic Fibrosis in Rats. J Liver. 2015; 4(2): 1-7. DOI: 10.4172/21670889.1000178", 
      "Ghosh A, Ghosh T, Jain S. Silymarin-A review on the pharmacodynamics and bioavailability enhancement approaches. J Pharm Sci Techn. 2010; 2(10): 348-55. Disponible en: JPST10-02-10-04.pdf", 
      "Bahmani M, Shirzad H, Rafieian S, Rafieian-Kopaei M. Silybum marianum: Beyond Hepatoprotection. J Evid Based Complementary Altern Med. 2015; 20(4): 292-301. DOI: 10.1177/2156587215571116", 
      "Luangchosiri C, Thakkinstian A, Chitphuk S, Stitchantrakul W, Petraksa S, Sobhonslidsuk A. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury. BMC Complement Altern Med. 2015; 15(334): 1-7. DOI: 10.1186/s12906015-0861-7", 
      "Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, et al. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother Res. 2006; 20(12): 1036-9. DOI: 10.1002/ptr.1988", 
      "Hagag A, Elgamsy M, El-Asy H, Mabrouk M. Protective Role of Silymarin on Hepatic and Renal Toxicity Induced by MTX Based Chemotherapy in Children with Acute Lymphoblastic Leukemia. Mediterr J Hematol Infect Dis. 2016; 8(1): 1-9. DOI: 10.4084/MJHID.2016.043", 
      "Roozbeh J, Shahriyari B, Akmali M, Vessal G, Pakfetrat M, Jalali GAR, et al. Comparative Effects of Silymarin and Vitamin E Supplementation on Oxidative Stress Markers, and Hemoglobin Levels Among Patients on Hemodialysis. Ren Fail. 2011; 33(2): 118-23. DOI: 10.3109/0886022x.2010.541579", 
      "Salmond S, George J, Strasser S, Byth K, Rawlinson B, Mori T, et al. Hep573 Study: A randomised, double-blind, placebo-controlled trial of silymarin alone and combined with antioxidants to improve liver function and quality of life in people with chronic hepatitis C. Aust J Herb Med. 2018; 30 (1): 12-25.", 
      "Fried MW, Navarro VJ, Afdhal N, Belle SH, Wahed AS, Hawke RL, et al. Effect of Silymarin (Milk Thistle) on Liver Disease in Patients with Chronic Hepatitis C Unsuccessfully Treated with Interferon Therapy A Randomized Controlled Trial. JAMA. 2012; 308(3): 274-82. DOI: 10.1001/jama.2012.8265", 
      "Tanamly M, Tadros F, Labeeb S, Makld H, Shehata M, Mikhail N, et al. Randomised double-blinded trial evaluating silymarin for chronic hepatitis C in an Egyptian village: study description and 12-month results. Dig Liver Dis. 2004; 36(11): 752-9. DOI: 10.1016/j.dld.2004.06.015"
    "keywords": [
    "publication_date": "2019-12-31", 
    "creators": [
        "orcid": "0000-0002-9379-5601", 
        "affiliation": "Unidad de Investigaci\u00f3n M\u00e9dica en Farmacolog\u00eda, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Ciudad de M\u00e9xico, M\u00e9xico.", 
        "name": "Jim\u00e9nez-Arellanes, Mar\u00eda Adelina"
    "access_right": "open", 
    "resource_type": {
      "subtype": "article", 
      "type": "publication", 
      "title": "Journal article"
    "related_identifiers": [
        "scheme": "doi", 
        "identifier": "10.5281/zenodo.3903936", 
        "relation": "isVersionOf"
All versions This version
Views 284284
Downloads 415415
Data volume 411.6 MB411.6 MB
Unique views 270270
Unique downloads 394394


Cite as