Journal article Open Access

A Path Towards Eliminating Malaria: Drug Resistance A Major Roadblock?

Ahmad, Sultan; Ahmad, Aqeel; Aziz, Alkama

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    <subfield code="a">A Path Towards Eliminating Malaria: Drug Resistance A Major Roadblock?</subfield>
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    <subfield code="a">Malaria has remained a life threatening disease in South-East Asia and Sub-Saharan Africa for decades. Many eff orts have been
spent on Global and regional surveillance of malaria burden. Over US$ 2.7 billion was invested in malaria control and elimination globally
in 2018. Insecticide-treated mosquito nets, rapid diagnostic tests andArtemisinin-based combination therapy are the three major pillars
that malaria control and elimination currently relies on. Insecticide resistances as well as the anti-malarial drug resistance have emerged
as the major road blocks in winning the war against malaria. Here we discuss in details the artemisinin chemotherapy, the resistance
phenotypes associated with its widespread use and the molecular marker associated with artemisinin drug resistance. Specifi cally we
discuss the surveillanceof K13 genotypes as an essential step in tracking the ART drug resistance in malaria laden areas</subfield>
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