Journal article Open Access

A Path Towards Eliminating Malaria: Drug Resistance A Major Roadblock?

Ahmad, Sultan; Ahmad, Aqeel; Aziz, Alkama

Malaria has remained a life threatening disease in South-East Asia and Sub-Saharan Africa for decades. Many eff orts have been spent on Global and regional surveillance of malaria burden. Over US$ 2.7 billion was invested in malaria control and elimination globally in 2018. Insecticide-treated mosquito nets, rapid diagnostic tests andArtemisinin-based combination therapy are the three major pillars that malaria control and elimination currently relies on. Insecticide resistances as well as the anti-malarial drug resistance have emerged as the major road blocks in winning the war against malaria. Here we discuss in details the artemisinin chemotherapy, the resistance phenotypes associated with its widespread use and the molecular marker associated with artemisinin drug resistance. Specifi cally we discuss the surveillanceof K13 genotypes as an essential step in tracking the ART drug resistance in malaria laden areas

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