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An open letter to Oran and Topol, and the Annals of Internal Medicine

Muge Cevik; Isaac I Bogoch; Gail Carson; Eric D'Ortenzio; Krutika Kuppalli; Nicola Low; Sara Loree; Alasdair Munro; Lina Moses; Harish Nair; Piero Olliaro; Louise Sigfrid; Renaud Vatrinet; on behalf of the CORRE Network (International COVID-19 Rapid Evidence Reviews Group)


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  <identifier identifierType="DOI">10.5281/zenodo.3892925</identifier>
  <creators>
    <creator>
      <creatorName>Muge Cevik</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-1133-3874</nameIdentifier>
      <affiliation>1Division of Infection and Global Health Research, School of Medicine, University of St Andrews, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Isaac I Bogoch</creatorName>
      <affiliation>2Division of Infectious Diseases, Toronto General Hospital and University of Toronto, Canada</affiliation>
    </creator>
    <creator>
      <creatorName>Gail Carson</creatorName>
      <affiliation>3 ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Eric D'Ortenzio</creatorName>
      <affiliation>4INSERM (The Institut national de la santé et de la recherche médicale), Paris, France</affiliation>
    </creator>
    <creator>
      <creatorName>Krutika Kuppalli</creatorName>
      <affiliation>5Division of Infectious Diseases Medical University of South Carolina, Charleston, South Carolina, USA</affiliation>
    </creator>
    <creator>
      <creatorName>Nicola Low</creatorName>
      <affiliation>6 Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland</affiliation>
    </creator>
    <creator>
      <creatorName>Sara Loree</creatorName>
      <affiliation>7 The Global Outbreak Alert and Response Network (GOARN), Geneva, Switzerland</affiliation>
    </creator>
    <creator>
      <creatorName>Alasdair Munro</creatorName>
      <affiliation>8 NIHR Southampton Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK 9 Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, Hampshire, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Lina Moses</creatorName>
      <affiliation>7 The Global Outbreak Alert and Response Network (GOARN), Geneva, Switzerland</affiliation>
    </creator>
    <creator>
      <creatorName>Harish Nair</creatorName>
      <affiliation>10 Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Piero Olliaro</creatorName>
      <affiliation>3 ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Louise Sigfrid</creatorName>
      <affiliation>3 ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Renaud Vatrinet</creatorName>
      <affiliation>4INSERM (The Institut national de la santé et de la recherche médicale), Paris, France</affiliation>
    </creator>
    <creator>
      <creatorName>on behalf of the CORRE Network (International COVID-19 Rapid Evidence Reviews Group)</creatorName>
    </creator>
  </creators>
  <titles>
    <title>An open letter to Oran and Topol, and the Annals of Internal Medicine</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2020</publicationYear>
  <subjects>
    <subject>asymptomatic infections</subject>
    <subject>SARS-CoV-2</subject>
    <subject>COVID-19</subject>
    <subject>systematic review</subject>
    <subject>evidence synthesis</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2020-06-10</date>
  </dates>
  <resourceType resourceTypeGeneral="Preprint"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/3892925</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.3888341</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/covid-19</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/zenodo</relatedIdentifier>
  </relatedIdentifiers>
  <version>version 2</version>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;An open letter to Oran and Topol, authors of&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;&amp;ldquo;Prevelance of Asymptomatic SARS-CoV-2 Infection: A Narrative Review&amp;rdquo; Annals of Internal Medicine. 2020 June 3. https://doi.org/10.7326/M20-3012&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;and Christine Laine (editor-in-chief The Annals of Internal Medicine)&lt;/p&gt;

&lt;p&gt;There is a need to better understand the contribution of asymptomatic SARS-CoV-2 infections (those with no symptoms at all throughout the infection) in driving the current pandemic. However, there are caveats that in our opinion are pertinent when interpreting the reported findings of this review, including the lack of a clear definition of asymptomatic infection and selective inclusion of cross-sectional studies. In addition, there is a problematic interpretation of a narrative review containing a dearth of poor-quality evidence resulting in an overestimate of asymptomatic infections, which might misinform policy response.&lt;/p&gt;</description>
  </descriptions>
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