November 28, 2019 Journal article Open Access

Schöllnberger, Helmut; Kaiser, Jan Christian; Eidemüller, Markus; Zablotska, Lydia B

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{
  "inLanguage": {
    "alternateName": "eng", 
    "@type": "Language", 
    "name": "English"
  }, 
  "description": "<p>Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose fractionated X-rays in 1930s-1950s and were followed-up for death from non-cancer causes during 1950-1987. In the current analysis, we scrutinized the assumption of linearity by analyzing a series of radio-biologically motivated nonlinear dose-response models to get a better understanding of the impact of radiation damage on IHD. The models were weighted according to their quality of fit and were then mathematically superposed applying the multi-model inference (MMI) technique. Our results indicated an essentially linear dose-response relationship for IHD mortality at low and medium doses and a supra-linear relationship at higher doses (&gt; 1.5 Gy). At 5 Gy, the estimated radiation risks were fivefold higher compared to the linear no-threshold (LNT) model. This is the largest study of patients exposed to fractionated low-to-moderate doses of radiation. Our analyses confirm previously reported significantly increased radiation risks of IHD from doses similar to those from diagnostic radiation procedures.</p>", 
  "license": "https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany; Division UR-Environmental Radioactivity, Federal Office for Radiation Protection, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany", 
      "@id": "https://orcid.org/0000-0002-4398-6565", 
      "@type": "Person", 
      "name": "Sch\u00f6llnberger, Helmut"
    }, 
    {
      "affiliation": "Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany", 
      "@id": "https://orcid.org/0000-0003-0359-2251", 
      "@type": "Person", 
      "name": "Kaiser, Jan Christian"
    }, 
    {
      "affiliation": "Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany", 
      "@id": "https://orcid.org/0000-0003-0249-3710", 
      "@type": "Person", 
      "name": "Eidem\u00fcller, Markus"
    }, 
    {
      "affiliation": "Department of Epidemiology and Biostatistics, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA", 
      "@id": "https://orcid.org/0000-0002-0778-1108", 
      "@type": "Person", 
      "name": "Zablotska,  Lydia B"
    }
  ], 
  "headline": "Radio-biologically Motivated Modeling of Radiation Risks of Mortality From Ischemic Heart Diseases in the Canadian Fluoroscopy Cohort Study", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2019-11-28", 
  "url": "https://zenodo.org/record/3878206", 
  "keywords": [
    "Ionizing radiation", 
    "Ischemic heart disease", 
    "LNT model", 
    "Multi-model inference", 
    "Nonlinear dose-response"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1007/s00411-019-00819-9", 
  "@id": "https://doi.org/10.1007/s00411-019-00819-9", 
  "@type": "ScholarlyArticle", 
  "name": "Radio-biologically Motivated Modeling of Radiation Risks of Mortality From Ischemic Heart Diseases in the Canadian Fluoroscopy Cohort Study"
}