{ "access": { "embargo": { "active": false, "reason": null }, "files": "public", "record": "public", "status": "open" }, "created": "2020-06-05T09:41:56.216380+00:00", "custom_fields": { "journal:journal": { "pages": "63\u201378", "title": "Radiation and Environmental Biophysics", "volume": "59" } }, "deletion_status": { "is_deleted": false, "status": "P" }, "files": { "count": 1, "enabled": true, "entries": { "IHD_Canadian_Fluoroscopy_Cohort.pdf": { "checksum": "md5:77c6cea22aeff38bd4e940792a7155a5", "ext": "pdf", "id": "3b4e1c52-e408-47b0-9b11-4a5802caee78", "key": "IHD_Canadian_Fluoroscopy_Cohort.pdf", "metadata": null, "mimetype": "application/pdf", "size": 10475602 } }, "order": [], "total_bytes": 10475602 }, "id": "3878206", "is_draft": false, "is_published": true, "links": { "access": "https://zenodo.org/api/records/3878206/access", "access_links": "https://zenodo.org/api/records/3878206/access/links", "access_request": "https://zenodo.org/api/records/3878206/access/request", "access_users": "https://zenodo.org/api/records/3878206/access/users", "archive": "https://zenodo.org/api/records/3878206/files-archive", "archive_media": "https://zenodo.org/api/records/3878206/media-files-archive", "communities": "https://zenodo.org/api/records/3878206/communities", "communities-suggestions": "https://zenodo.org/api/records/3878206/communities-suggestions", "doi": "https://doi.org/10.1007/s00411-019-00819-9", "draft": "https://zenodo.org/api/records/3878206/draft", "files": "https://zenodo.org/api/records/3878206/files", "latest": "https://zenodo.org/api/records/3878206/versions/latest", "latest_html": "https://zenodo.org/records/3878206/latest", "media_files": "https://zenodo.org/api/records/3878206/media-files", "parent": "https://zenodo.org/api/records/3878205", "parent_doi": "https://zenodo.org/doi/", "parent_html": "https://zenodo.org/records/3878205", "requests": "https://zenodo.org/api/records/3878206/requests", "reserve_doi": "https://zenodo.org/api/records/3878206/draft/pids/doi", "self": "https://zenodo.org/api/records/3878206", "self_doi": "https://zenodo.org/doi/10.1007/s00411-019-00819-9", "self_html": "https://zenodo.org/records/3878206", "self_iiif_manifest": "https://zenodo.org/api/iiif/record:3878206/manifest", "self_iiif_sequence": "https://zenodo.org/api/iiif/record:3878206/sequence/default", "versions": "https://zenodo.org/api/records/3878206/versions" }, "media_files": { "count": 0, "enabled": false, "entries": {}, "order": [], "total_bytes": 0 }, "metadata": { "additional_descriptions": [ { "description": "This work was supported by a project from the Federal Office for Radiation Protection (BfS) (contract no. 3615S42221). The project has also received funding from the Euratom research and training program 2014-2018 under grant agreement No 755523 (MEDIRAD). Dr. Zablotska's work was supported by the National Cancer Institute of the National Institutes of Health (award numbers R03CA188614 and R01CA197422).\n\nThis is a post-peer-review, pre-copyedit version of an article published in Radiation and Environmental Biophysics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00411-019-00819-9", "type": { "id": "notes", "title": { "de": "Anmerkungen", "en": "Notes" } } } ], "creators": [ { "affiliations": [ { "name": "Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany; Division UR-Environmental Radioactivity, Federal Office for Radiation Protection, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany" } ], "person_or_org": { "family_name": "Sch\u00f6llnberger", "given_name": "Helmut", "identifiers": [ { "identifier": "0000-0002-4398-6565", "scheme": "orcid" } ], "name": "Sch\u00f6llnberger, Helmut", "type": "personal" } }, { "affiliations": [ { "name": "Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany" } ], "person_or_org": { "family_name": "Kaiser", "given_name": "Jan Christian", "identifiers": [ { "identifier": "0000-0003-0359-2251", "scheme": "orcid" } ], "name": "Kaiser, Jan Christian", "type": "personal" } }, { "affiliations": [ { "name": "Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstrasse 1, 85764, Neuherberg, Germany" } ], "person_or_org": { "family_name": "Eidem\u00fcller", "given_name": "Markus", "identifiers": [ { "identifier": "0000-0003-0249-3710", "scheme": "orcid" } ], "name": "Eidem\u00fcller, Markus", "type": "personal" } }, { "affiliations": [ { "name": "Department of Epidemiology and Biostatistics, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA" } ], "person_or_org": { "family_name": "Zablotska", "given_name": "Lydia B", "identifiers": [ { "identifier": "0000-0002-0778-1108", "scheme": "orcid" } ], "name": "Zablotska, Lydia B", "type": "personal" } } ], "description": "
Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose fractionated X-rays in 1930s-1950s and were followed-up for death from non-cancer causes during 1950-1987. In the current analysis, we scrutinized the assumption of linearity by analyzing a series of radio-biologically motivated nonlinear dose-response models to get a better understanding of the impact of radiation damage on IHD. The models were weighted according to their quality of fit and were then mathematically superposed applying the multi-model inference (MMI) technique. Our results indicated an essentially linear dose-response relationship for IHD mortality at low and medium doses and a supra-linear relationship at higher doses (> 1.5 Gy). At 5 Gy, the estimated radiation risks were fivefold higher compared to the linear no-threshold (LNT) model. This is the largest study of patients exposed to fractionated low-to-moderate doses of radiation. Our analyses confirm previously reported significantly increased radiation risks of IHD from doses similar to those from diagnostic radiation procedures.
", "funding": [ { "award": { "acronym": "MEDIRAD", "id": "00k4n6c32::755523", "identifiers": [ { "identifier": "https://cordis.europa.eu/projects/755523", "scheme": "url" } ], "number": "755523", "program": "H2020", "title": { "en": "Implications of Medical Low Dose Radiation Exposure" } }, "funder": { "id": "00k4n6c32", "name": "European Commission" } } ], "languages": [ { "id": "eng", "title": { "en": "English" } } ], "publication_date": "2019-11-28", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "" }, "icon": "cc-by-nc-nd-icon", "id": "cc-by-nc-nd-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution Non Commercial No Derivatives 4.0 International" } } ], "subjects": [ { "subject": "Ionizing radiation" }, { "subject": "Ischemic heart disease" }, { "subject": "LNT model" }, { "subject": "Multi-model inference" }, { "subject": "Nonlinear dose-response" } ], "title": "Radio-biologically Motivated Modeling of Radiation Risks of Mortality From Ischemic Heart Diseases in the Canadian Fluoroscopy Cohort Study" }, "parent": { "access": { "owned_by": { "user": 104916 } }, "communities": { "entries": [ { "access": { "member_policy": "open", "members_visibility": "restricted", "record_policy": "open", "review_policy": "closed", "visibility": "public" }, "children": { "allow": true }, "created": "2022-11-23T15:53:29.436323+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "f0a8b890-f97a-4eb2-9eac-8b8a712d3a6c", "links": {}, "metadata": { "curation_policy": "The EU Open Research Repository serves as a repository for research outputs (data, software, posters, presentations, publications, etc) which have been funded under an EU research funding programme such as Horizon Europe, Euratom or earlier Framework Programmes.
\nThe community is managed by CERN on behalf of the European Commission.
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", "description": "Open repository for EU-funded research outputs from Horizon Europe, Euratom and earlier Framework Programmes.", "organizations": [ { "id": "00k4n6c32" } ], "page": "The EU Open Research Repository is a Zenodo-community dedicated to fostering open science and enhancing the visibility and accessibility of research outputs funded by the European Union. The community is managed by CERN on behalf of the European Commission.
\nThe mission of the repository is to support the implementation of the EU's open science policy, providing a trusted and comprehensive space for researchers to share their research outputs such as data, software, reports, presentations, posters and more. The EU Open Research Repository simplifies the process of complying with open science requirements, ensuring that research outputs from Horizon Europe, Euratom, and earlier Framework Programmes are freely accessible, thereby accelerating scientific discovery and innovation.
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