November 28, 2019 Journal article Open Access

Schöllnberger, Helmut; Kaiser, Jan Christian; Eidemüller, Markus; Zablotska, Lydia B

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  <identifier identifierType="URL">https://zenodo.org/record/3878206</identifier>
  <creators>
    <creator>
      <creatorName>Schöllnberger, Helmut</creatorName>
      <givenName>Helmut</givenName>
      <familyName>Schöllnberger</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-4398-6565</nameIdentifier>
      <affiliation>Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany; Division UR-Environmental Radioactivity, Federal Office for Radiation Protection, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Kaiser, Jan Christian</creatorName>
      <givenName>Jan Christian</givenName>
      <familyName>Kaiser</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0359-2251</nameIdentifier>
      <affiliation>Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Eidemüller, Markus</creatorName>
      <givenName>Markus</givenName>
      <familyName>Eidemüller</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0249-3710</nameIdentifier>
      <affiliation>Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Zablotska,  Lydia B</creatorName>
      <givenName>Lydia B</givenName>
      <familyName>Zablotska</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0778-1108</nameIdentifier>
      <affiliation>Department of Epidemiology and Biostatistics, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Radio-biologically Motivated Modeling of Radiation Risks of Mortality From Ischemic Heart Diseases in the Canadian Fluoroscopy Cohort Study</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2019</publicationYear>
  <subjects>
    <subject>Ionizing radiation</subject>
    <subject>Ischemic heart disease</subject>
    <subject>LNT model</subject>
    <subject>Multi-model inference</subject>
    <subject>Nonlinear dose-response</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2019-11-28</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="JournalArticle"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/3878206</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s00411-019-00819-9</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode">Creative Commons Attribution Non Commercial No Derivatives 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose fractionated X-rays in 1930s-1950s and were followed-up for death from non-cancer causes during 1950-1987. In the current analysis, we scrutinized the assumption of linearity by analyzing a series of radio-biologically motivated nonlinear dose-response models to get a better understanding of the impact of radiation damage on IHD. The models were weighted according to their quality of fit and were then mathematically superposed applying the multi-model inference (MMI) technique. Our results indicated an essentially linear dose-response relationship for IHD mortality at low and medium doses and a supra-linear relationship at higher doses (&amp;gt; 1.5 Gy). At 5 Gy, the estimated radiation risks were fivefold higher compared to the linear no-threshold (LNT) model. This is the largest study of patients exposed to fractionated low-to-moderate doses of radiation. Our analyses confirm previously reported significantly increased radiation risks of IHD from doses similar to those from diagnostic radiation procedures.&lt;/p&gt;</description>
    <description descriptionType="Other">This work was supported by a project from the Federal Office for Radiation Protection (BfS) (contract no. 3615S42221). The project has also received funding from the Euratom research and training program 2014-2018 under grant agreement No 755523 (MEDIRAD). Dr. Zablotska's work was supported by the National Cancer Institute of the National Institutes of Health (award numbers R03CA188614 and R01CA197422).

This is a post-peer-review, pre-copyedit version of an article published in Radiation and Environmental Biophysics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00411-019-00819-9</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/100010661</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/H2020/755523/">755523</awardNumber>
      <awardTitle>Implications of Medical Low Dose Radiation Exposure</awardTitle>
    </fundingReference>
  </fundingReferences>
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