Radio-biologically Motivated Modeling of Radiation Risks of Mortality From Ischemic Heart Diseases in the Canadian Fluoroscopy Cohort Study

Schöllnberger, Helmut; Kaiser, Jan Christian; Eidemüller, Markus; Zablotska,  Lydia B

doi:10.1007/s00411-019-00819-9

November 28, 2019 Journal article Open Access

Radio-biologically Motivated Modeling of Radiation Risks of Mortality From Ischemic Heart Diseases in the Canadian Fluoroscopy Cohort Study

Schöllnberger, Helmut; Kaiser, Jan Christian; Eidemüller, Markus; Zablotska, Lydia B

DCAT Export

<?xml version='1.0' encoding='utf-8'?>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:adms="http://www.w3.org/ns/adms#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dct="http://purl.org/dc/terms/" xmlns:dctype="http://purl.org/dc/dcmitype/" xmlns:dcat="http://www.w3.org/ns/dcat#" xmlns:duv="http://www.w3.org/ns/duv#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:frapo="http://purl.org/cerif/frapo/" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:gsp="http://www.opengis.net/ont/geosparql#" xmlns:locn="http://www.w3.org/ns/locn#" xmlns:org="http://www.w3.org/ns/org#" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:prov="http://www.w3.org/ns/prov#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:schema="http://schema.org/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:vcard="http://www.w3.org/2006/vcard/ns#" xmlns:wdrs="http://www.w3.org/2007/05/powder-s#">
  <rdf:Description rdf:about="https://zenodo.org/record/3878206">
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/3878206</dct:identifier>
    <foaf:page rdf:resource="https://zenodo.org/record/3878206"/>
    <dct:creator>
      <rdf:Description rdf:about="http://orcid.org/0000-0002-4398-6565">
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0000-0002-4398-6565</dct:identifier>
        <foaf:name>Schöllnberger, Helmut</foaf:name>
        <foaf:givenName>Helmut</foaf:givenName>
        <foaf:familyName>Schöllnberger</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany; Division UR-Environmental Radioactivity, Federal Office for Radiation Protection, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description rdf:about="http://orcid.org/0000-0003-0359-2251">
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0000-0003-0359-2251</dct:identifier>
        <foaf:name>Kaiser, Jan Christian</foaf:name>
        <foaf:givenName>Jan Christian</foaf:givenName>
        <foaf:familyName>Kaiser</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description rdf:about="http://orcid.org/0000-0003-0249-3710">
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0000-0003-0249-3710</dct:identifier>
        <foaf:name>Eidemüller, Markus</foaf:name>
        <foaf:givenName>Markus</foaf:givenName>
        <foaf:familyName>Eidemüller</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Department of Radiation Sciences, Institute of Radiation Medicine, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description rdf:about="http://orcid.org/0000-0002-0778-1108">
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0000-0002-0778-1108</dct:identifier>
        <foaf:name>Zablotska, Lydia B</foaf:name>
        <foaf:givenName>Lydia B</foaf:givenName>
        <foaf:familyName>Zablotska</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Department of Epidemiology and Biostatistics, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:title>Radio-biologically Motivated Modeling of Radiation Risks of Mortality From Ischemic Heart Diseases in the Canadian Fluoroscopy Cohort Study</dct:title>
    <dct:publisher>
      <foaf:Agent>
        <foaf:name>Zenodo</foaf:name>
      </foaf:Agent>
    </dct:publisher>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2019</dct:issued>
    <dcat:keyword>Ionizing radiation</dcat:keyword>
    <dcat:keyword>Ischemic heart disease</dcat:keyword>
    <dcat:keyword>LNT model</dcat:keyword>
    <dcat:keyword>Multi-model inference</dcat:keyword>
    <dcat:keyword>Nonlinear dose-response</dcat:keyword>
    <frapo:isFundedBy rdf:resource="info:eu-repo/grantAgreement/EC/H2020/755523/"/>
    <schema:funder>
      <foaf:Organization>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/100010661</dct:identifier>
        <foaf:name>European Commission</foaf:name>
      </foaf:Organization>
    </schema:funder>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2019-11-28</dct:issued>
    <dct:language rdf:resource="http://publications.europa.eu/resource/authority/language/ENG"/>
    <owl:sameAs rdf:resource="https://zenodo.org/record/3878206"/>
    <adms:identifier>
      <adms:Identifier>
        <skos:notation rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/3878206</skos:notation>
        <adms:schemeAgency>url</adms:schemeAgency>
      </adms:Identifier>
    </adms:identifier>
    <owl:sameAs rdf:resource="https://doi.org/10.1007/s00411-019-00819-9"/>
    <dct:description>&lt;p&gt;Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose fractionated X-rays in 1930s-1950s and were followed-up for death from non-cancer causes during 1950-1987. In the current analysis, we scrutinized the assumption of linearity by analyzing a series of radio-biologically motivated nonlinear dose-response models to get a better understanding of the impact of radiation damage on IHD. The models were weighted according to their quality of fit and were then mathematically superposed applying the multi-model inference (MMI) technique. Our results indicated an essentially linear dose-response relationship for IHD mortality at low and medium doses and a supra-linear relationship at higher doses (&amp;gt; 1.5 Gy). At 5 Gy, the estimated radiation risks were fivefold higher compared to the linear no-threshold (LNT) model. This is the largest study of patients exposed to fractionated low-to-moderate doses of radiation. Our analyses confirm previously reported significantly increased radiation risks of IHD from doses similar to those from diagnostic radiation procedures.&lt;/p&gt;</dct:description>
    <dct:description>This work was supported by a project from the Federal Office for Radiation Protection (BfS) (contract no. 3615S42221). The project has also received funding from the Euratom research and training program 2014-2018 under grant agreement No 755523 (MEDIRAD). Dr. Zablotska's work was supported by the National Cancer Institute of the National Institutes of Health (award numbers R03CA188614 and R01CA197422). This is a post-peer-review, pre-copyedit version of an article published in Radiation and Environmental Biophysics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00411-019-00819-9</dct:description>
    <dct:accessRights rdf:resource="http://publications.europa.eu/resource/authority/access-right/PUBLIC"/>
    <dct:accessRights>
      <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess">
        <rdfs:label>Open Access</rdfs:label>
      </dct:RightsStatement>
    </dct:accessRights>
    <dct:license rdf:resource="https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"/>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL rdf:resource="https://doi.org/10.1007/s00411-019-00819-9"/>
        <dcat:byteSize>10475602</dcat:byteSize>
        <dcat:downloadURL rdf:resource="https://zenodo.org/record/3878206/files/IHD_Canadian_Fluoroscopy_Cohort.pdf"/>
        <dcat:mediaType>application/pdf</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
  </rdf:Description>
  <foaf:Project rdf:about="info:eu-repo/grantAgreement/EC/H2020/755523/">
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">755523</dct:identifier>
    <dct:title>Implications of Medical Low Dose Radiation Exposure</dct:title>
    <frapo:isAwardedBy>
      <foaf:Organization>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/100010661</dct:identifier>
        <foaf:name>European Commission</foaf:name>
      </foaf:Organization>
    </frapo:isAwardedBy>
  </foaf:Project>
</rdf:RDF>

views

downloads

See more details...