November 28, 2019 Journal article Open Access

Schöllnberger, Helmut; Kaiser, Jan Christian; Eidemüller, Markus; Zablotska, Lydia B

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{
  "note": "This work was supported by a project from the Federal Office for Radiation Protection (BfS) (contract no. 3615S42221). The project has also received funding from the Euratom research and training program 2014-2018 under grant agreement No 755523 (MEDIRAD). Dr. Zablotska's work was supported by the National Cancer Institute of the National Institutes of Health (award numbers R03CA188614 and R01CA197422).\n\nThis is a post-peer-review, pre-copyedit version of an article published in Radiation and Environmental Biophysics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00411-019-00819-9", 
  "DOI": "10.1007/s00411-019-00819-9", 
  "container_title": "Radiation and Environmental Biophysics", 
  "language": "eng", 
  "title": "Radio-biologically Motivated Modeling of Radiation Risks of Mortality From Ischemic Heart Diseases in the Canadian Fluoroscopy Cohort Study", 
  "issued": {
    "date-parts": [
      [
        2019, 
        11, 
        28
      ]
    ]
  }, 
  "abstract": "<p>Recent analyses of the Canadian fluoroscopy cohort study reported significantly increased radiation risks of mortality from ischemic heart diseases (IHD) with a linear dose-response adjusted for dose fractionation. This cohort includes 63,707 tuberculosis patients from Canada who were exposed to low-to-moderate dose fractionated X-rays in 1930s-1950s and were followed-up for death from non-cancer causes during 1950-1987. In the current analysis, we scrutinized the assumption of linearity by analyzing a series of radio-biologically motivated nonlinear dose-response models to get a better understanding of the impact of radiation damage on IHD. The models were weighted according to their quality of fit and were then mathematically superposed applying the multi-model inference (MMI) technique. Our results indicated an essentially linear dose-response relationship for IHD mortality at low and medium doses and a supra-linear relationship at higher doses (&gt; 1.5 Gy). At 5 Gy, the estimated radiation risks were fivefold higher compared to the linear no-threshold (LNT) model. This is the largest study of patients exposed to fractionated low-to-moderate doses of radiation. Our analyses confirm previously reported significantly increased radiation risks of IHD from doses similar to those from diagnostic radiation procedures.</p>", 
  "author": [
    {
      "family": "Sch\u00f6llnberger, Helmut"
    }, 
    {
      "family": "Kaiser, Jan Christian"
    }, 
    {
      "family": "Eidem\u00fcller, Markus"
    }, 
    {
      "family": "Zablotska,  Lydia B"
    }
  ], 
  "page": "63\u201378", 
  "volume": "59", 
  "type": "article-journal", 
  "id": "3878206"
}