Journal article Open Access

''DESIGN, SYNTHESIS AND CHARACTERIZATION OF SOME NEW 2-AMINO PYRIMIDINE DERIVATIVES''

Dr.Siddharth Desai, Anand S.N., Dr. Kishore Singh C., Dr. Ashok Malpani.


DCAT Export

<?xml version='1.0' encoding='utf-8'?>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:adms="http://www.w3.org/ns/adms#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dct="http://purl.org/dc/terms/" xmlns:dctype="http://purl.org/dc/dcmitype/" xmlns:dcat="http://www.w3.org/ns/dcat#" xmlns:duv="http://www.w3.org/ns/duv#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:frapo="http://purl.org/cerif/frapo/" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:gsp="http://www.opengis.net/ont/geosparql#" xmlns:locn="http://www.w3.org/ns/locn#" xmlns:org="http://www.w3.org/ns/org#" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:prov="http://www.w3.org/ns/prov#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:schema="http://schema.org/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:vcard="http://www.w3.org/2006/vcard/ns#" xmlns:wdrs="http://www.w3.org/2007/05/powder-s#">
  <rdf:Description rdf:about="https://doi.org/10.5281/zenodo.3871146">
    <rdf:type rdf:resource="http://www.w3.org/ns/dcat#Dataset"/>
    <dct:type rdf:resource="http://purl.org/dc/dcmitype/Text"/>
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://doi.org/10.5281/zenodo.3871146</dct:identifier>
    <foaf:page rdf:resource="https://doi.org/10.5281/zenodo.3871146"/>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Dr.Siddharth Desai, Anand S.N., Dr. Kishore Singh C., Dr. Ashok Malpani.</foaf:name>
        <foaf:givenName>Anand S.N., Dr. Kishore Singh C., Dr. Ashok Malpani.</foaf:givenName>
        <foaf:familyName>Dr.Siddharth Desai</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society's College of Pharmacy, Balaji Nagar, Jewargi Old Road, Kalaburagi-585102, Karnataka, India.</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:title>''DESIGN, SYNTHESIS AND CHARACTERIZATION OF SOME NEW 2-AMINO PYRIMIDINE DERIVATIVES''</dct:title>
    <dct:publisher>
      <foaf:Agent>
        <foaf:name>Zenodo</foaf:name>
      </foaf:Agent>
    </dct:publisher>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2020</dct:issued>
    <dcat:keyword>Chalcones, Pyrimidines, Anti-Bacterial, Antifungal.</dcat:keyword>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2020-06-01</dct:issued>
    <owl:sameAs rdf:resource="https://zenodo.org/record/3871146"/>
    <adms:identifier>
      <adms:Identifier>
        <skos:notation rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/3871146</skos:notation>
        <adms:schemeAgency>url</adms:schemeAgency>
      </adms:Identifier>
    </adms:identifier>
    <dct:isVersionOf rdf:resource="https://doi.org/10.5281/zenodo.3871145"/>
    <dct:isPartOf rdf:resource="https://zenodo.org/communities/iajpr"/>
    <dct:description>&lt;p&gt;2-substituted derivatives of indane-1,3-diones &amp;nbsp;have shown many activities. Chalcones possess a number of biological and pharmacological activities such as antibacterial, antifungal, antimalarial, anti-inflammatory, anticancer, anti-tubercular, and antioxidant activities etc. The synthesis of chalcone compounds incorporating with heterocycles became great importance in medicinal chemistry. Literature survey revealed that Chalcones and Pyrimidine derivatives&amp;nbsp; possess a broad spectrum of biological activities like antimicrobial, anti-inflammatory, antimalarial, antitubercular, anticancer, antidepressant and antamoebic etc.Hence an attempt is made to synthesize some new chalcones from 2- acetyl-indane- 1,3- dione with various substituted aromatic/ heteroaromatic aldehydes by the Claisen &amp;ndash; Schmidt condensation. The resulted chalcones have been converted into their 2-amino pyrimidine derivatives by reaction with guanidine hydrochloride. The resulted compounds were identified by physical and spectral methods and were also screened for their antibacterial and antifungal activities based on the reported literature.&amp;nbsp;2-substituted derivatives of indane-1,3-diones &amp;nbsp;have shown many activities. Chalcones possess a number of biological and pharmacological activities such as antibacterial, antifungal, antimalarial, anti-inflammatory, anticancer, anti-tubercular, and antioxidant activities etc. The synthesis of chalcone compounds incorporating with heterocycles became great importance in medicinal chemistry. Literature survey revealed that Chalcones and Pyrimidine derivatives&amp;nbsp; possess a broad spectrum of biological activities like antimicrobial, anti-inflammatory, antimalarial, antitubercular, anticancer, antidepressant and antamoebic etc.Hence an attempt is made to synthesize some new chalcones from 2- acetyl-indane- 1,3- dione with various substituted aromatic/ heteroaromatic aldehydes by the Claisen &amp;ndash; Schmidt condensation. The resulted chalcones have been converted into their 2-amino pyrimidine derivatives by reaction with guanidine hydrochloride. The resulted compounds were identified by physical and spectral methods and were also screened for their antibacterial and antifungal activities based on the reported literature.&amp;nbsp;&lt;/p&gt;</dct:description>
    <dct:accessRights rdf:resource="http://publications.europa.eu/resource/authority/access-right/PUBLIC"/>
    <dct:accessRights>
      <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess">
        <rdfs:label>Open Access</rdfs:label>
      </dct:RightsStatement>
    </dct:accessRights>
    <dcat:distribution>
      <dcat:Distribution>
        <dct:license rdf:resource="https://creativecommons.org/licenses/by/4.0/legalcode"/>
        <dcat:accessURL rdf:resource="https://doi.org/10.5281/zenodo.3871146"/>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3871146</dcat:accessURL>
        <dcat:byteSize>673931</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3871146/files/200207.pdf</dcat:downloadURL>
        <dcat:mediaType>application/pdf</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
  </rdf:Description>
</rdf:RDF>
69
74
views
downloads
All versions This version
Views 6969
Downloads 7474
Data volume 49.9 MB49.9 MB
Unique views 6363
Unique downloads 6969

Share

Cite as