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Ischemic stroke is considered one of the most threatening neurological disorders with high percentages of mortality and morbidity worldwide. Although in recent years, several nanotechnological advances have improved the survival rates, severe untreated poststroke side\u2010effects continue to significantly influence the way of life of many. Tissue plasminogen activator and mechanical thrombectomy are considered the gold standards for the treatment of acute cerebral ischemia. These, however, fail to improve postischemic disorders. Herein, after a brief description of the pathophysiology of ischemic stroke and the following biochemical cascade, the most recent biomaterial and cell\u2010based strategies are reviewed for its treatment. Other therapeutics that have been proposed not only for the treatment of cerebral ischemia but also for the regeneration of the infarcted brain that is responsible for a variety of disorders, including cognitive, motor, and speech problems are also presented. Finally, a few reported studies on diagnostic and theranostic nanostructures are also provided.
", "funding": [ { "award": { "acronym": "BIONICS", "id": "00k4n6c32::793644", "identifiers": [ { "identifier": "https://cordis.europa.eu/projects/793644", "scheme": "url" } ], "number": "793644", "program": "H2020", "title": { "en": "A biomimetic and neuroprotective delivery nanocapsule for the targeted treatment of post-ischemic stroke effects" } }, "funder": { "id": "00k4n6c32", "name": "European Commission" } } ], "publication_date": "2019-10-30", "publisher": "Zenodo", "resource_type": { "id": "publication-preprint", "title": { "de": "Preprint", "en": "Preprint" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "title": "Advanced Functional Materials and Cell\u2010Based Therapies for the Treatment of Ischemic Stroke and Postischemic Stroke Effects" }, "parent": { "access": { "owned_by": { "user": 44465 } }, "communities": { "default": "1e0eece3-377c-41fd-bd5e-d92dd2fe264c", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2018-10-22T12:58:56.725880+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "1e0eece3-377c-41fd-bd5e-d92dd2fe264c", "links": {}, "metadata": { "curation_policy": "", "page": "This MSCA project aims at overcoming the limitations of the current available strategies for the treatment of post-ischemic stroke effects by introducing 'BIONICS', which represents a biomimetic and neuroprotective delivery nanocapsule. Its novelty lies to the enhanced delivery of various reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavengers across the blood brain barrier (BBB), and the amelioration of the post-ischemic stroke symptoms through hypoxia and oxidative stress regulation.
", "title": "A biomimetic and neuroprotective delivery nanocapsule for the targeted treatment of post-ischemic stroke effects" }, "revision_id": 0, "slug": "bionics", "updated": "2020-05-13T10:03:02.576174+00:00" }, { "access": { "member_policy": "open", "members_visibility": "restricted", "record_policy": "open", "review_policy": "closed", "visibility": "public" }, "children": { "allow": true }, "created": "2022-11-23T15:53:29.436323+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "f0a8b890-f97a-4eb2-9eac-8b8a712d3a6c", "links": {}, "metadata": { "curation_policy": "The EU Open Research Repository serves as a repository for research outputs (data, software, posters, presentations, publications, etc) which have been funded under an EU research funding programme such as Horizon Europe, Euratom or earlier Framework Programmes.
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", "description": "Open repository for EU-funded research outputs from Horizon Europe, Euratom and earlier Framework Programmes.", "organizations": [ { "id": "00k4n6c32" } ], "page": "The EU Open Research Repository is a Zenodo-community dedicated to fostering open science and enhancing the visibility and accessibility of research outputs funded by the European Union. The community is managed by CERN on behalf of the European Commission.
\nThe mission of the repository is to support the implementation of the EU's open science policy, providing a trusted and comprehensive space for researchers to share their research outputs such as data, software, reports, presentations, posters and more. The EU Open Research Repository simplifies the process of complying with open science requirements, ensuring that research outputs from Horizon Europe, Euratom, and earlier Framework Programmes are freely accessible, thereby accelerating scientific discovery and innovation.
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