Dataset Open Access

Not only pulmonary rehabilitation for critically ill patients with COVID-19

Anna Estraneo; Marco Ciapetti; Carlo Gaudiosi; Antonello Grippo

DataCite XML Export

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="" xmlns="" xsi:schemaLocation="">
  <identifier identifierType="DOI">10.5281/zenodo.3783636</identifier>
      <creatorName>Anna Estraneo</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="">0000-0001-6646-5626</nameIdentifier>
      <affiliation>IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy; Neurology Unit, SM della Pietà General Hospital, Nola, Italy</affiliation>
      <creatorName>Marco Ciapetti</creatorName>
      <affiliation>Cure Intensive del trauma e delle gravi insufficienze d'organo, AOU Careggi, Florence, Italy</affiliation>
      <creatorName>Carlo Gaudiosi</creatorName>
      <affiliation>COVID Unit, General Hospital, Boscotrecase, Italy</affiliation>
      <creatorName>Antonello Grippo</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="">0000-0002-9997-8564</nameIdentifier>
      <affiliation>IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy; SODc Neurofisiopatologia, AOU Careggi, Florence, Italy</affiliation>
    <title>Not only pulmonary rehabilitation for critically ill patients with COVID-19</title>
    <date dateType="Issued">2020-05-03</date>
  <resourceType resourceTypeGeneral="Dataset"/>
    <alternateIdentifier alternateIdentifierType="url"></alternateIdentifier>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.3783635</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf"></relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf"></relatedIdentifier>
    <rights rightsURI="">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
    <description descriptionType="Abstract">&lt;p&gt;&lt;strong&gt;Background&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Prolonged immobility in COVID-19 patients in mechanical ventilation combined with the infection-mediated harmful immune response can be responsible of peripheral nervous system complications, such as Intensive Care Unit Acquired Weakness (ICU-AW). We report preliminary findings of our monocentric prospective study.&lt;/p&gt;


&lt;p&gt;Prospective observational study of PCR-confirmed COVID-19 patients in mechanical ventilation in the Intensive Care Unit of Azienda Ospedaliero Universitaria Careggi (Firenze).&amp;nbsp;We evaluated: 1. muscle power grading on motor response to nociceptive stimuli by means of MRC; 2. nerve conduction velocities, compound muscle action potentials (CMAP) and sensory nerve action potentials (SNAP) of six motor and four sensitive nerves in bilateral upper and lower limbs; 3. spontaneous muscle activity in bilateral tibialis anterior and biceps by needle. The presence of combined critical illness polyneuropathy and myopathy (CIPNM) was defined by very low amplitude of CMAP and/or SNAP on neurophysiological evaluation with normal or mildly reduced nerve conduction velocities, combined with myopathic features on needle electromyography.&amp;nbsp;Data about pre-existing comorbidities such as diabetes and hypertension were also collected.&lt;/p&gt;


&lt;p&gt;Between March 23 March 2020 to 10 April 2020, we performed ENG studies in 9 patients. Based on clinical examination&amp;nbsp;ICU-AW (MRC score &amp;lt;48/60) was present in all 9 patients. Four of them had diagnosis of CIPNM at neurophysiological evaluation, and 3 of the remaining 5 patients presented neurophysiological findings consistent with common peroneal nerve compression&lt;/p&gt;


&lt;p&gt;The present findings suggest that in critically ill patients affected by COVID-19 functional motor deficits are highly prevalent and should be searched for. ICU-AW have been found to negatively affect weaning from mechanical ventilation long-term outcome&amp;nbsp;and increase in-hospital mortality of critical patients. Early recognition of these complications could help clinicians to plan an appropriate neuromotor rehabilitation (e.g. by early passive limbs mobilization and posture changes) for improving respiratory function and clinical outcome.&lt;/p&gt;



All versions This version
Views 293293
Downloads 9797
Data volume 58.1 kB58.1 kB
Unique views 251251
Unique downloads 9090


Cite as