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Methodological approaches for personalised medicine: protocol for a series of scoping reviews

Banzi, Rita; Gerardi, Chiara; Fratelli, Maddalena; Garcia, Paula; Teresa Torres; Josep Maria Haro Abad; Albert Sanchez Niubo; Enrico Glaab; Emanuela Oldoni; Florence Bietrix; Vibeke Fosse; Emmet McCormack; Raphael Porcher; Cecilia Superchi; Jacques Demotes-Mainard


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{
  "inLanguage": {
    "alternateName": "aig", 
    "@type": "Language", 
    "name": "Antigua and Barbuda Creole English"
  }, 
  "description": "<p>This is the protocol for a series of scoping reviews that will map the general concept of methods for personalised medicine, to set the basis for the discussion on robustness and reproducibility of personalised medicine development programmes. The final goal is the identification of standards and needs in terms of methodology of data generation, management, analysis and interpretation to improve clinical studies in personalised medicine.</p>\n\n<p>For the purpose of this review, four main aspects of the general concept of personalised medicine will be analysed:</p>\n\n<ul>\n\t<li>Methods for stratification and validation cohorts</li>\n\t<li>Methods for machine learning applied to stratification</li>\n\t<li>Pre-clinical methods for translational development of treatment options and treatments selection</li>\n\t<li>Methods for clinical trials in personalised medicine</li>\n</ul>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy", 
      "@type": "Person", 
      "name": "Banzi, Rita"
    }, 
    {
      "affiliation": "Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy", 
      "@type": "Person", 
      "name": "Gerardi, Chiara"
    }, 
    {
      "affiliation": "Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy", 
      "@type": "Person", 
      "name": "Fratelli, Maddalena"
    }, 
    {
      "affiliation": "European Clinical Research Infrastructure Network (ECRIN), Paris, France", 
      "@type": "Person", 
      "name": "Garcia, Paula"
    }, 
    {
      "affiliation": "Parc Sanitari San Joan de D\u00e9u, San Boi del Llobregat, Barcelona, Spain", 
      "@type": "Person", 
      "name": "Teresa Torres"
    }, 
    {
      "affiliation": "Parc Sanitari San Joan de D\u00e9u, San Boi del Llobregat, Barcelona, Spain", 
      "@type": "Person", 
      "name": "Josep Maria Haro Abad"
    }, 
    {
      "affiliation": "Parc Sanitari San Joan de D\u00e9u, San Boi del Llobregat, Barcelona, Spain", 
      "@type": "Person", 
      "name": "Albert Sanchez Niubo"
    }, 
    {
      "affiliation": "Luxembourg CentrUniversit\u00e9 du Luxembourg, Luxembourg", 
      "@type": "Person", 
      "name": "Enrico Glaab"
    }, 
    {
      "affiliation": "European infrastructure for Translational Medicine, (EATRIS), Amsterdam, The Netherlands", 
      "@type": "Person", 
      "name": "Emanuela Oldoni"
    }, 
    {
      "affiliation": "European infrastructure for Translational Medicine, (EATRIS), Amsterdam, The Netherlands", 
      "@type": "Person", 
      "name": "Florence Bietrix"
    }, 
    {
      "affiliation": "University of Bergen, Bergen, Norway", 
      "@type": "Person", 
      "name": "Vibeke Fosse"
    }, 
    {
      "affiliation": "University of Bergen, Bergen, Norway", 
      "@type": "Person", 
      "name": "Emmet McCormack"
    }, 
    {
      "affiliation": "Universit\u00e9 Paris Descartes, Paris, France", 
      "@type": "Person", 
      "name": "Raphael Porcher"
    }, 
    {
      "affiliation": "Universit\u00e9 Paris Descartes, Paris, France", 
      "@type": "Person", 
      "name": "Cecilia Superchi"
    }, 
    {
      "affiliation": "European Clinical Research Infrastructure Network (ECRIN), Paris, France", 
      "@type": "Person", 
      "name": "Jacques Demotes-Mainard"
    }
  ], 
  "url": "https://zenodo.org/record/3770937", 
  "datePublished": "2020-04-30", 
  "version": "V2_20200429", 
  "keywords": [
    "personalised medicine", 
    "methods", 
    "clinical trials", 
    "scoping review"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.3770937", 
  "@id": "https://doi.org/10.5281/zenodo.3770937", 
  "@type": "CreativeWork", 
  "name": "Methodological approaches for personalised medicine: protocol for a series of scoping reviews"
}
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