Journal article Open Access

Impact of a Daily Probiotic (Lactobacillus casei Shirota) for 12 Months on the Frequency of Diverticulitis Episodes: Feasibility Study in Primary Care.

John Nichols*; Barbara Engel; Linda V. Thomas; Paul Grob; Michelle Dobrota Gibbs; Peter Williams; Tamara Fenton; Simon de Lusignan


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    "description": "<p><strong>Background:</strong>Some small secondary care studies have shown benefits from taking probiotics in diverticular disease. We investigated the feasibility of conducting a year-long probiotic study in primary care.</p>\n\n<p><strong>Methods:</strong>Patients (n=21) with a past history of uncomplicated acute diverticulitis but not currently taking antibiotics were recruited from four general practices. Subjects were asked to take the daily probiotic drink Yakult&Ograve;. Probiotic effects were assessed by comparing clinically diagnosed diverticulitis attacks in the 6 months prior to probiotic intervention with the 0-6 and 6-12 month periods after probiotic intervention commenced. Effects on gastrointestinal symptoms were assessed by validated questionnaires at baseline, 6 and 12 months. Diet diaries were also completed.</p>\n\n<p><strong>Results: </strong>Two thirds (14/21) of subjects who demonstrated good adherence in taking the daily probiotic improved symptomatically (p=0.025). Clinical presentations with diverticulitis were down 50% during the study period compared with the 12 months period before (7 vs 14 cases; p=0.021). The mean change in gastrointestinal symptom score improved significantly (p &lt;0.001). Diverticulitis episodes did not correlate with body mass index (BMI), diabetic status or dietary fibre.&nbsp;</p>\n\n<p><strong>Conclusions: </strong>Taking the daily probiotic was associated with a lower rate of clinical presentation with diverticulitis episodes and improvement in gastrointestinal symptoms. Sufficient information is presented to design a definitive trial. However, we recommend inclusion of a method to validate the diagnosis of diverticulitis. It is feasible to recruit and run a study that requires participants to take a daily probiotic drink for a year in a primary care setting.</p>\n\n<p>LACTOPRoD was registered at ClinicalTrials.gov:&nbsp;NCT01609751 in 2012.</p>", 
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    "title": "Impact of a Daily Probiotic (Lactobacillus casei Shirota) for 12 Months on the Frequency of Diverticulitis Episodes: Feasibility Study in Primary Care.", 
    "journal": {
      "volume": "2", 
      "issue": "1", 
      "pages": "1-10", 
      "title": "Archives of Nutrition and Public Health"
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    "keywords": [
      "Keywords: Dietary fibre; Diverticulitis; Gastrointestinal symptoms; Lactobacillus casei Shirota; Primary care; Probiotic"
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    "publication_date": "2020-03-25", 
    "creators": [
      {
        "affiliation": "60 Manor Way, Onslow Village, Guildford, Surrey GU2 7RR, UK", 
        "name": "John Nichols*"
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      {
        "affiliation": "Department of Nutritional Sciences, Faculty of Health and Medical Sciences, Duke of Kent Building, University of Surrey, Guildford, Surrey GU2 7TE", 
        "name": "Barbara Engel"
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      {
        "affiliation": "Queen's Avenue, Dorchester, DT1 2EP, formerly at Yakult UK Limited, Odyssey Business Park, West End Road, South Ruislip HA4 6QQ, UK", 
        "name": "Linda V. Thomas"
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      {
        "affiliation": "Department of Clinical Medicine and Ageing, University of Surrey, Guildford, Surrey GU2 7XH, UK.", 
        "name": "Paul Grob"
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      {
        "affiliation": "Expert Nutrition Works, Whimple, Exeter, EX5 2PP", 
        "name": "Michelle Dobrota Gibbs"
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      {
        "affiliation": "Department of Mathematics, University of Surrey, Guildford, Surrey GU2 7XH, UK.", 
        "name": "Peter Williams"
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      {
        "affiliation": "Nutrition and Dietetic Service (Cambridge and Peterborough NHS Foundation Trust), First Floor, Sackville House, Sackville Way, Cambourne, Cambridgeshire, CB23 6HL", 
        "name": "Tamara Fenton"
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      {
        "affiliation": "Department of Clinical Medicine and Ageing, University of Surrey, Guildford, Surrey GU2 7XH, UK.", 
        "name": "Simon de Lusignan"
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