Journal article Open Access

Jensenone from eucalyptus essential oil as a potential inhibitor of COVID 19 corona virus infection

Arun Dev Sharma*, Inderjeet Kaur

DCAT Export

<?xml version='1.0' encoding='utf-8'?>
<rdf:RDF xmlns:rdf="" xmlns:adms="" xmlns:dc="" xmlns:dct="" xmlns:dctype="" xmlns:dcat="" xmlns:duv="" xmlns:foaf="" xmlns:frapo="" xmlns:geo="" xmlns:gsp="" xmlns:locn="" xmlns:org="" xmlns:owl="" xmlns:prov="" xmlns:rdfs="" xmlns:schema="" xmlns:skos="" xmlns:vcard="" xmlns:wdrs="">
  <rdf:Description rdf:about="">
    <dct:identifier rdf:datatype=""></dct:identifier>
    <foaf:page rdf:resource=""/>
        <rdf:type rdf:resource=""/>
        <foaf:name>Arun Dev Sharma*, Inderjeet Kaur</foaf:name>
        <foaf:givenName>Inderjeet Kaur</foaf:givenName>
        <foaf:familyName>Arun Dev Sharma*</foaf:familyName>
    <dct:title>Jensenone from eucalyptus essential oil as a potential inhibitor of COVID 19 corona virus infection</dct:title>
    <dct:issued rdf:datatype="">2020</dct:issued>
    <dct:issued rdf:datatype="">2020-04-11</dct:issued>
    <owl:sameAs rdf:resource=""/>
        <skos:notation rdf:datatype=""></skos:notation>
    <dct:isVersionOf rdf:resource=""/>
    <dct:description>&lt;p&gt;COVID-19, a member of corona virus family is spreading its tentacles&lt;br&gt; across the world due to lack of drugs at present. However, the main&lt;br&gt; viral proteinase (Mpro/3CLpro) has recently been regarded as a&lt;br&gt; suitable target for drug design against SARS infection due to its vital&lt;br&gt; role in polyproteins processing necessary for coronavirus&lt;br&gt; reproduction. The present in silico study was designed to evaluate&lt;br&gt; the effect of Jensenone, a essential oil component from eucalyptus oil,&lt;br&gt; on Mpro by docking study. In the present study, molecular docking&lt;br&gt; studies were conducted by using 1-click dock and swiss dock tools.&lt;br&gt; Protein interaction mode was calculated by Protein Interactions&lt;br&gt; Calculator.The calculated parameters such as binding energy, and&lt;br&gt; binding site similarity indicated effective binding of Jensenone to&lt;br&gt; COVID-19 proteinase. Active site prediction further validated the&lt;br&gt; role of active site residues in ligand binding. PIC results indicated&lt;br&gt; that, Mpro/ Jensenone complexes forms hydrophobic interactions,&lt;br&gt; hydrogen bond interactions and strong ionic interactions. Therefore,&lt;br&gt; Jensenone may represent potential treatment potential to act as&lt;br&gt; COVID-19 Mpro inhibitor. However, further research is necessary to&lt;br&gt; investigate their potential medicinal use.&lt;br&gt; Keywords: COVID-19, Essential oil,&lt;/p&gt;</dct:description>
    <dct:accessRights rdf:resource=""/>
      <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess">
        <rdfs:label>Open Access</rdfs:label>
    <dct:license rdf:resource=""/>
        <dcat:accessURL rdf:resource=""/>
        <dcat:downloadURL rdf:resource=""/>
All versions This version
Views 818818
Downloads 571571
Data volume 297.3 MB297.3 MB
Unique views 727727
Unique downloads 534534


Cite as