There is a newer version of this record available.

Report Open Access

Statistical review of A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 by B. Cao et al

Gates, Simon; Emsley, Richard; Dahly, Darren

JSON Export

  "files": [
      "links": {
        "self": ""
      "checksum": "md5:c139dbcfe8d74902ab4682026f95e384", 
      "bucket": "30634491-18bf-48b3-9469-f5881daa7c8c", 
      "key": "Review_20_03_28_Cao.pdf", 
      "type": "pdf", 
      "size": 148916
  "owners": [
  "doi": "10.5281/zenodo.3746512", 
  "stats": {
    "version_unique_downloads": 731.0, 
    "unique_views": 886.0, 
    "views": 997.0, 
    "version_views": 1318.0, 
    "unique_downloads": 521.0, 
    "version_unique_views": 1133.0, 
    "volume": 84435372.0, 
    "version_downloads": 885.0, 
    "downloads": 567.0, 
    "version_volume": 131947380.0
  "links": {
    "doi": "", 
    "conceptdoi": "", 
    "bucket": "", 
    "conceptbadge": "", 
    "html": "", 
    "latest_html": "", 
    "badge": "", 
    "latest": ""
  "conceptdoi": "10.5281/zenodo.3746511", 
  "created": "2020-04-09T15:37:45.116458+00:00", 
  "updated": "2020-04-13T06:25:46.876460+00:00", 
  "conceptrecid": "3746511", 
  "revision": 6, 
  "id": 3746512, 
  "metadata": {
    "access_right_category": "success", 
    "doi": "10.5281/zenodo.3746512", 
    "description": "<p>The following review has been prepared in collaboration with members of the MRC-NIHR Trials Methodology Research Partnership. The reviewers named above, and other, unnamed discussants of the paper, are all qualified statisticians with experience in clinical&nbsp; trials. Our objective is to provide a rapid review of publications, preprints and protocols from clinical trials of COVID-19 treatments,&nbsp; independent of journal specific review processes. We aim to provide timely, constructive, focused, clear advice aimed at improving both the research outputs under review, as well as future studies. Given our collective expertise (clinical trial statistics) our reviews&nbsp; focus on the designs of the trials and other statistical content (methods, presentation and accuracy of results, inferences). Here we review <em>A Trial of Lopinavir&ndash;Ritonavir in Adults Hospitalized with Severe Covid-19</em>, by B.Cao <em>et al</em>, published in the New England Journal of Medicine on 18 March 2020. This was one of the first randomised controlled trials of treatments for COVID-19 to be published, and the first in a high-profile medical journal.</p>", 
    "language": "eng", 
    "title": "Statistical review of A Trial of Lopinavir\u2013Ritonavir in Adults Hospitalized with Severe Covid-19 by B. Cao et al", 
    "license": {
      "id": "CC-BY-4.0"
    "relations": {
      "version": [
          "count": 2, 
          "index": 0, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "3746511"
          "is_last": false, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "3749469"
    "communities": [
        "id": "covid-19-tx-rct-stats-review"
        "id": "zenodo"
    "version": "1.0", 
    "keywords": [
      "clinical trials", 
    "publication_date": "2020-04-09", 
    "creators": [
        "affiliation": "Professor of Biostatistics and Clinical Trials, Cancer Research UK Clinical Trials Unit, University of Birmingham, UK", 
        "name": "Gates, Simon"
        "affiliation": "NIHR Research Professor & Professor of Medical Statistics and Trials Methodology, Department of Biostatistics and Health Informatics, King's College London, UK", 
        "name": "Emsley, Richard"
        "affiliation": "Principal Statistician, HRB Clinical Research Facility - Cork. HRB Trials Methodology Research Network. Senior Lecturer in Patient Focused Research Methods, University College Cork School of Public Health", 
        "name": "Dahly, Darren"
    "access_right": "open", 
    "resource_type": {
      "subtype": "report", 
      "type": "publication", 
      "title": "Report"
    "related_identifiers": [
        "scheme": "doi", 
        "identifier": "10.5281/zenodo.3746511", 
        "relation": "isVersionOf"
All versions This version
Views 1,318997
Downloads 885567
Data volume 131.9 MB84.4 MB
Unique views 1,133886
Unique downloads 731521


Cite as