10.5281/zenodo.3746512
https://zenodo.org/records/3746512
oai:zenodo.org:3746512
Gates, Simon
Simon
Gates
Professor of Biostatistics and Clinical Trials, Cancer Research UK Clinical Trials Unit, University of Birmingham, UK
Emsley, Richard
Richard
Emsley
NIHR Research Professor & Professor of Medical Statistics and Trials Methodology, Department of Biostatistics and Health Informatics, King's College London, UK
Dahly, Darren
Darren
Dahly
Principal Statistician, HRB Clinical Research Facility - Cork. HRB Trials Methodology Research Network. Senior Lecturer in Patient Focused Research Methods, University College Cork School of Public Health
Statistical review of A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 by B. Cao et al
Zenodo
2020
COVID-19
clinical trials
RCTs
Lopinavir
Ritonavir
2020-04-09
eng
10.5281/zenodo.3746511
https://zenodo.org/communities/covid-19-tx-rct-stats-review
1.0
Creative Commons Attribution 4.0 International
The following review has been prepared in collaboration with members of the MRC-NIHR Trials Methodology Research Partnership. The reviewers named above, and other, unnamed discussants of the paper, are all qualified statisticians with experience in clinical trials. Our objective is to provide a rapid review of publications, preprints and protocols from clinical trials of COVID-19 treatments, independent of journal specific review processes. We aim to provide timely, constructive, focused, clear advice aimed at improving both the research outputs under review, as well as future studies. Given our collective expertise (clinical trial statistics) our reviews focus on the designs of the trials and other statistical content (methods, presentation and accuracy of results, inferences). Here we review A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19, by B.Cao et al, published in the New England Journal of Medicine on 18 March 2020. This was one of the first randomised controlled trials of treatments for COVID-19 to be published, and the first in a high-profile medical journal.