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Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial .

Dahly, Darren; Gates, Simon; Morris, Tim


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    <subfield code="a">&lt;p&gt;The following review has been prepared by members of the MRC-NIHR Trials Methodology Research Partnership. The reviewers are all qualified statisticians with experience in clinical trials. Our objective is to provide a rapid review of publications, preprints and protocols from clinical trials of COVID-19 treatments, independent of journal specific review processes. We aim to provide timely, constructive, focused, clear advice aimed at improving both the&amp;nbsp; research outputs under review, as well as future studies. Given our collective expertise (clinical trial statistics) our reviews focus on&amp;nbsp; the designs of the trials and other statistical content (methods, presentation and accuracy of results, inferences).&lt;/p&gt;

&lt;p&gt;Here we review &lt;em&gt;Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical&amp;nbsp; trial&lt;/em&gt;, by Gautret et al . When we started our review, the paper was being circulated via Google Drive. Shortly after, it was accepted&amp;nbsp; for publication in the International Journal of Antimicrobial Agents, and posted on MedRxiv.org. However, these versions of the&amp;nbsp; study report were the same as the one we reviewed, indicating no or limited external peer review for the final published version.&lt;/p&gt;</subfield>
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