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Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial .

Dahly, Darren; Gates, Simon; Morris, Tim


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{
  "inLanguage": {
    "alternateName": "eng", 
    "@type": "Language", 
    "name": "English"
  }, 
  "description": "<p>The following review has been prepared by members of the MRC-NIHR Trials Methodology Research Partnership. The reviewers are all qualified statisticians with experience in clinical trials. Our objective is to provide a rapid review of publications, preprints and protocols from clinical trials of COVID-19 treatments, independent of journal specific review processes. We aim to provide timely, constructive, focused, clear advice aimed at improving both the&nbsp; research outputs under review, as well as future studies. Given our collective expertise (clinical trial statistics) our reviews focus on&nbsp; the designs of the trials and other statistical content (methods, presentation and accuracy of results, inferences).</p>\n\n<p>Here we review <em>Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical&nbsp; trial</em>, by Gautret et al . When we started our review, the paper was being circulated via Google Drive. Shortly after, it was accepted&nbsp; for publication in the International Journal of Antimicrobial Agents, and posted on MedRxiv.org. However, these versions of the&nbsp; study report were the same as the one we reviewed, indicating no or limited external peer review for the final published version.</p>", 
  "license": "http://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "HRB Clinical Research Facility - Cork. HRB Trial Methodology Research Network. University College Cork School of Public Health", 
      "@type": "Person", 
      "name": "Dahly, Darren"
    }, 
    {
      "affiliation": "Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, UK", 
      "@type": "Person", 
      "name": "Gates, Simon"
    }, 
    {
      "affiliation": "MRC Clinical Trials Unit at University College London", 
      "@type": "Person", 
      "name": "Morris, Tim"
    }
  ], 
  "headline": "Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial .", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2020-03-23", 
  "url": "https://zenodo.org/record/3725560", 
  "version": "1.1", 
  "keywords": [
    "Randomized Clinical Trials", 
    "COVID-19", 
    "Hydroxychloroquine", 
    "Azithromycin"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.3725560", 
  "@id": "https://doi.org/10.5281/zenodo.3725560", 
  "@type": "ScholarlyArticle", 
  "name": "Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial ."
}
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