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Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial .

Dahly, Darren; Gates, Simon; Morris, Tim


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  <identifier identifierType="DOI">10.5281/zenodo.3725560</identifier>
  <creators>
    <creator>
      <creatorName>Dahly, Darren</creatorName>
      <givenName>Darren</givenName>
      <familyName>Dahly</familyName>
      <affiliation>HRB Clinical Research Facility - Cork. HRB Trial Methodology Research Network. University College Cork School of Public Health</affiliation>
    </creator>
    <creator>
      <creatorName>Gates, Simon</creatorName>
      <givenName>Simon</givenName>
      <familyName>Gates</familyName>
      <affiliation>Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Morris, Tim</creatorName>
      <givenName>Tim</givenName>
      <familyName>Morris</familyName>
      <affiliation>MRC Clinical Trials Unit at University College London</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial .</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2020</publicationYear>
  <subjects>
    <subject>Randomized Clinical Trials</subject>
    <subject>COVID-19</subject>
    <subject>Hydroxychloroquine</subject>
    <subject>Azithromycin</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2020-03-23</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="Text">Report</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/3725560</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.3724166</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/covid-19-tx-rct-stats-review</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/zenodo</relatedIdentifier>
  </relatedIdentifiers>
  <version>1.1</version>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The following review has been prepared by members of the MRC-NIHR Trials Methodology Research Partnership. The reviewers are all qualified statisticians with experience in clinical trials. Our objective is to provide a rapid review of publications, preprints and protocols from clinical trials of COVID-19 treatments, independent of journal specific review processes. We aim to provide timely, constructive, focused, clear advice aimed at improving both the&amp;nbsp; research outputs under review, as well as future studies. Given our collective expertise (clinical trial statistics) our reviews focus on&amp;nbsp; the designs of the trials and other statistical content (methods, presentation and accuracy of results, inferences).&lt;/p&gt;

&lt;p&gt;Here we review &lt;em&gt;Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical&amp;nbsp; trial&lt;/em&gt;, by Gautret et al . When we started our review, the paper was being circulated via Google Drive. Shortly after, it was accepted&amp;nbsp; for publication in the International Journal of Antimicrobial Agents, and posted on MedRxiv.org. However, these versions of the&amp;nbsp; study report were the same as the one we reviewed, indicating no or limited external peer review for the final published version.&lt;/p&gt;</description>
  </descriptions>
</resource>
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