Journal article Open Access

PNA-Based Dynamic Combinatorial libraries (PDCL) and screening of lectins

Lluc Farrera-Soler; Jean-Pierre Daguer; Patrick Raunft; Anne Imberty; Sofia Barluenga; Nicolas Winssinger


DCAT Export

<?xml version='1.0' encoding='utf-8'?>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:adms="http://www.w3.org/ns/adms#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dct="http://purl.org/dc/terms/" xmlns:dctype="http://purl.org/dc/dcmitype/" xmlns:dcat="http://www.w3.org/ns/dcat#" xmlns:duv="http://www.w3.org/ns/duv#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:frapo="http://purl.org/cerif/frapo/" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:gsp="http://www.opengis.net/ont/geosparql#" xmlns:locn="http://www.w3.org/ns/locn#" xmlns:org="http://www.w3.org/ns/org#" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:prov="http://www.w3.org/ns/prov#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:schema="http://schema.org/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:vcard="http://www.w3.org/2006/vcard/ns#" xmlns:wdrs="http://www.w3.org/2007/05/powder-s#">
  <rdf:Description rdf:about="https://doi.org/10.5281/zenodo.3712677">
    <rdf:type rdf:resource="http://www.w3.org/ns/dcat#Dataset"/>
    <dct:type rdf:resource="http://purl.org/dc/dcmitype/Text"/>
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://doi.org/10.5281/zenodo.3712677</dct:identifier>
    <foaf:page rdf:resource="https://doi.org/10.5281/zenodo.3712677"/>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Lluc Farrera-Soler</foaf:name>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>University of Geneva</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Jean-Pierre Daguer</foaf:name>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>University of Geneva</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Patrick Raunft</foaf:name>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>University of Geneva</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description rdf:about="http://orcid.org/0000-0001-6825-9527">
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0000-0001-6825-9527</dct:identifier>
        <foaf:name>Anne Imberty</foaf:name>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Université Grenoble Alpes</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description rdf:about="http://orcid.org/0000-0003-3830-1178">
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0000-0003-3830-1178</dct:identifier>
        <foaf:name>Sofia Barluenga</foaf:name>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>University of Geneva</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description rdf:about="http://orcid.org/0000-0003-1636-7766">
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0000-0003-1636-7766</dct:identifier>
        <foaf:name>Nicolas Winssinger</foaf:name>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>University of Geneva</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:title>PNA-Based Dynamic Combinatorial libraries (PDCL) and screening of lectins</dct:title>
    <dct:publisher>
      <foaf:Agent>
        <foaf:name>Zenodo</foaf:name>
      </foaf:Agent>
    </dct:publisher>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2020</dct:issued>
    <frapo:isFundedBy rdf:resource="info:eu-repo/grantAgreement/SNSF/Project+funding/200020_169141/"/>
    <schema:funder>
      <foaf:Organization>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/501100001711</dct:identifier>
        <foaf:name>Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung</foaf:name>
      </foaf:Organization>
    </schema:funder>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2020-03-17</dct:issued>
    <owl:sameAs rdf:resource="https://zenodo.org/record/3712677"/>
    <adms:identifier>
      <adms:Identifier>
        <skos:notation rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/3712677</skos:notation>
        <adms:schemeAgency>url</adms:schemeAgency>
      </adms:Identifier>
    </adms:identifier>
    <dct:isVersionOf rdf:resource="https://doi.org/10.5281/zenodo.3712676"/>
    <dct:description>&lt;p&gt;Selection from dynamic combinatorial libraries (DCL) benefit from the dynamic nature of the library that can change constitution upon addition of a selection pressure, such as ligands binding to a protein. This technology has been predominantly used with small molecules interacting with each other through reversible covalent interaction. However, application of this technology in biomedical research and drug discovery has been limited by the reversibility of covalent exchange and the analytical deconvolution of small molecule fragments.&amp;nbsp;&amp;nbsp; Here we report a supramolecular approach based on the use of a constant short PNA tag to direct the combinatorial pairing of fragment.&amp;nbsp; This PNA tag yields fast exchange kinetics, while still delivering the benefits of cooperativity, and provides favourable properties for analytical deconvolution by MALDI.&amp;nbsp; A selection of &amp;gt; 6 000 assemblies of glycans (mono-, di-, tri-saccharides) targeting AFL, a lectin from pathogenic fungus, yielded a 95 nM assembly, nearly three orders of magnitude better affinity than the corresponding glycan alone (41 &amp;micro;M).&lt;/p&gt;</dct:description>
    <dct:accessRights rdf:resource="http://publications.europa.eu/resource/authority/access-right/PUBLIC"/>
    <dct:accessRights>
      <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess">
        <rdfs:label>Open Access</rdfs:label>
      </dct:RightsStatement>
    </dct:accessRights>
    <dcat:distribution>
      <dcat:Distribution>
        <dct:license rdf:resource="https://creativecommons.org/licenses/by/4.0/legalcode"/>
        <dcat:accessURL rdf:resource="https://doi.org/10.5281/zenodo.3712677"/>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>2143255</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Biotinyation RSL.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>6215177</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Biotinylation AFL.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>257653</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Full library starting library.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>35458</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Full selection RSL part 1.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>32482</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Full selection RSL part 2.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>32062</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Full selection RSL part 3.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>31218</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Full selection RSL part 4.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>14680</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/FUll selection RSL part 5</dcat:downloadURL>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>2887817</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/M0A.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>2709259</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/MKA.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>1831143</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/MXA.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>2468454</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/N0A.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>2700792</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/NKA.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>38753</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/No protein fucose glucose 1 to 1.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>38753</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/no protein fucose glucose 1 to 99.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>1831143</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/NXA.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>111603</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/RSL selection big library 60C.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>198054</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Selection AFL rt.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>237627</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Selection full library RSL rt.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>37858</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Selection RSL 1 to 1.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>37868</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Selection RSL fucose glucose 1 to 99.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>2295349</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Single sequence Fucose.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>3022906</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Single sequence glucose.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>706560</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/SPR_AFL_2fucosyllactose_alone</dcat:downloadURL>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>29592064</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/SPR_AFL_Hits</dcat:downloadURL>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>7863296</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/SPR_MOA_MXA_MKA_alone_with_AFL</dcat:downloadURL>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>7863296</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/SPR_MOA_MXA_MKA_alone_with_RSL</dcat:downloadURL>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>755200</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/SPR_RSL_2fucosyllactosealone</dcat:downloadURL>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>29585920</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/SPR_RSL_Hits</dcat:downloadURL>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>290634</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/starting lib 2fucosyllactose.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>297576</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting lib cellobiose.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>284399</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting lib GalSPhe.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>256424</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting lib GlcNAc cluster.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>204622</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting lib glucoseamine.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>299117</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting lib glucose.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>294688</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting lib GluNAc.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>295385</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting lib Maltose.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>279765</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting lib Mannose.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>45491</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting library 1 to 1 fucose glucose.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>37191</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting library fucose glucose 1 to 99.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.5281/zenodo.3712677</dcat:accessURL>
        <dcat:byteSize>285332</dcat:byteSize>
        <dcat:downloadURL>https://zenodo.org/record/3712677/files/Starting lib xylose.txt</dcat:downloadURL>
        <dcat:mediaType>text/plain</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
  </rdf:Description>
  <foaf:Project rdf:about="info:eu-repo/grantAgreement/SNSF/Project+funding/200020_169141/">
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">200020_169141</dct:identifier>
    <dct:title>Probes for chemical biology: from synthesis to biosupramolecular systems</dct:title>
    <frapo:isAwardedBy>
      <foaf:Organization>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/501100001711</dct:identifier>
        <foaf:name>Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung</foaf:name>
      </foaf:Organization>
    </frapo:isAwardedBy>
  </foaf:Project>
</rdf:RDF>
27
10
views
downloads
All versions This version
Views 2727
Downloads 1010
Data volume 34.9 MB34.9 MB
Unique views 2525
Unique downloads 99

Share

Cite as