Journal article Open Access

"DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF DALFAMPRIDINE, IN BULK AND PHARMACEUTICAL DOSAGE FORM."

Rathod K.G.


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    <subfield code="a">&lt;p&gt;A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Dalfampridine in its pure form as well as in tablet dosage form.&amp;nbsp; Chromatography was carried out on ODS C18 (4.6 x 250mm, 5&amp;micro;m) column using Acetonitrile and water in the ratio of 80:20 v/v,as the mobile phase at a flow rate of 1.0mL/min, The retention time obtained for DFP was 2.98 min. The method produce linear responses in the concentration range of 20 &amp;micro;g/ml of&amp;nbsp; Dalfampridine . The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.&lt;/p&gt;</subfield>
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