Journal article Open Access

"DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF DALFAMPRIDINE, IN BULK AND PHARMACEUTICAL DOSAGE FORM."

Rathod K.G.


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  <identifier identifierType="DOI">10.5281/zenodo.3597164</identifier>
  <creators>
    <creator>
      <creatorName>Rathod K.G.</creatorName>
      <affiliation>Mangaldeep Institute of Pharmacy, Nipani, Aurangabad.</affiliation>
    </creator>
  </creators>
  <titles>
    <title>"DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF DALFAMPRIDINE, IN BULK AND PHARMACEUTICAL DOSAGE FORM."</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2020</publicationYear>
  <subjects>
    <subject>Dalfampridine; RP-HPLC; PDA Detection; Validation; Tablet Dosage Forms.</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2020-01-03</date>
  </dates>
  <resourceType resourceTypeGeneral="JournalArticle"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/3597164</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.3597163</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/iajpr</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Dalfampridine in its pure form as well as in tablet dosage form.&amp;nbsp; Chromatography was carried out on ODS C18 (4.6 x 250mm, 5&amp;micro;m) column using Acetonitrile and water in the ratio of 80:20 v/v,as the mobile phase at a flow rate of 1.0mL/min, The retention time obtained for DFP was 2.98 min. The method produce linear responses in the concentration range of 20 &amp;micro;g/ml of&amp;nbsp; Dalfampridine . The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.&lt;/p&gt;</description>
  </descriptions>
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