Journal article Open Access

Detection of enriched T cell epitope specificity in full T cell receptor sequence repertoires

Gielis, Sofie; Moris, Pieter; Bittremieux, Wout; De Neuter, Nicolas; Ogunjimi, Benson; Laukens, Kris; Meysman, Pieter


DCAT Export

<?xml version='1.0' encoding='utf-8'?>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:adms="http://www.w3.org/ns/adms#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dct="http://purl.org/dc/terms/" xmlns:dctype="http://purl.org/dc/dcmitype/" xmlns:dcat="http://www.w3.org/ns/dcat#" xmlns:duv="http://www.w3.org/ns/duv#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:frapo="http://purl.org/cerif/frapo/" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:gsp="http://www.opengis.net/ont/geosparql#" xmlns:locn="http://www.w3.org/ns/locn#" xmlns:org="http://www.w3.org/ns/org#" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:prov="http://www.w3.org/ns/prov#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:schema="http://schema.org/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:vcard="http://www.w3.org/2006/vcard/ns#" xmlns:wdrs="http://www.w3.org/2007/05/powder-s#">
  <rdf:Description rdf:about="https://zenodo.org/record/3558267">
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/3558267</dct:identifier>
    <foaf:page rdf:resource="https://zenodo.org/record/3558267"/>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Gielis, Sofie</foaf:name>
        <foaf:givenName>Sofie</foaf:givenName>
        <foaf:familyName>Gielis</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Adrem Data Lab, Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Moris, Pieter</foaf:name>
        <foaf:givenName>Pieter</foaf:givenName>
        <foaf:familyName>Moris</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Adrem Data Lab, Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Bittremieux, Wout</foaf:name>
        <foaf:givenName>Wout</foaf:givenName>
        <foaf:familyName>Bittremieux</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Adrem Data Lab, Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>De Neuter, Nicolas</foaf:name>
        <foaf:givenName>Nicolas</foaf:givenName>
        <foaf:familyName>De Neuter</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Adrem Data Lab, Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Ogunjimi, Benson</foaf:name>
        <foaf:givenName>Benson</foaf:givenName>
        <foaf:familyName>Ogunjimi</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, Antwerp, Belgium</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Laukens, Kris</foaf:name>
        <foaf:givenName>Kris</foaf:givenName>
        <foaf:familyName>Laukens</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Adrem Data Lab, Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Meysman, Pieter</foaf:name>
        <foaf:givenName>Pieter</foaf:givenName>
        <foaf:familyName>Meysman</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Adrem Data Lab, Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:title>Detection of enriched T cell epitope specificity in full T cell receptor sequence repertoires</dct:title>
    <dct:publisher>
      <foaf:Agent>
        <foaf:name>Zenodo</foaf:name>
      </foaf:Agent>
    </dct:publisher>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2019</dct:issued>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2019-11-29</dct:issued>
    <owl:sameAs rdf:resource="https://zenodo.org/record/3558267"/>
    <adms:identifier>
      <adms:Identifier>
        <skos:notation rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/3558267</skos:notation>
        <adms:schemeAgency>url</adms:schemeAgency>
      </adms:Identifier>
    </adms:identifier>
    <owl:sameAs rdf:resource="https://doi.org/10.3389/fimmu.2019.02820"/>
    <dct:description>&lt;p&gt;High-throughput T cell receptor (TCR) sequencing allows the characterization of an individual&amp;#39;s TCR repertoire and directly queries their immune state. However, it remains a non-trivial task to couple these sequenced TCRs to their antigenic targets. In this paper, we present a novel strategy to annotate full TCR sequence repertoires with their epitope specificities. The strategy is based on a machine learning algorithm to learn the TCR patterns common to the recognition of a specific epitope. These results are then combined with a statistical analysis to evaluate the occurrence of specific epitope-reactive TCR sequences per epitope in repertoire data. In this manner, we can directly study the capacity of full TCR repertoires to target specific epitopes of the relevant vaccines or pathogens. We demonstrate the usability of this approach on three independent datasets related to vaccine monitoring and infectious disease diagnostics by independently identifying the epitopes that are targeted by the TCR repertoire. The developed method is freely available as a web tool for academic use at tcrex.biodatamining.be.&lt;/p&gt;</dct:description>
    <dct:accessRights rdf:resource="http://publications.europa.eu/resource/authority/access-right/PUBLIC"/>
    <dct:accessRights>
      <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess">
        <rdfs:label>Open Access</rdfs:label>
      </dct:RightsStatement>
    </dct:accessRights>
    <dct:license rdf:resource="https://creativecommons.org/licenses/by/4.0/legalcode"/>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL>https://doi.org/10.3389/fimmu.2019.02820</dcat:accessURL>
        <dcat:byteSize>721297</dcat:byteSize>
        <dcat:downloadURL rdf:resource="https://zenodo.org/record/3558267/files/Gielis2019.pdf">https://zenodo.org/record/3558267/files/Gielis2019.pdf</dcat:downloadURL>
        <dcat:mediaType>application/pdf</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
  </rdf:Description>
</rdf:RDF>
38
32
views
downloads
Views 38
Downloads 32
Data volume 23.1 MB
Unique views 38
Unique downloads 31

Share

Cite as