Published October 31, 2018
| Version v1
Preprint
Open
In vivo contactless brain nanothermometry
Creators
- 1. Centre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Mail H74 PO Box 218, Hawthorn, VIC 3122, Australia
- 2. IMDEA Nanoscience, Faraday 9, Campus Cantoblanco 28049, Madrid, Spain
- 3. Department of Anatomy, Histology and Neuroscience, Faculty of Medicine, Universidad Autónoma de Madrid, 28049 Madrid, Spain
- 4. Fluorescence Imaging Group, Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, 28049 Madrid, Spain
- 5. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
- 6. Fluorescence Imaging Group, Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, 28049 Madrid, Spain Instituto Ramon y Cajal de Investigaci�n Sanitaria (IRYCIS), Hospital Ram�n y Cajal, 28034 Madrid, Spain
- 7. Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), Hospital Ram�n y Cajal, 28034 Madrid, Spain Fluorescence Imaging Group, Department of Materials Physics, Faculty of Science, Universidad Autónoma de Madrid, 28049 Madrid, Spain
Description
Despite attracting increased attention from clinicians, brain temperature distribution, fluctuations and changes in response to external stimuli are still largely unknown and refractory to conventional temperature-probing approaches. Fluorescence nanothermometry in the second near-infrared window (NIR-II window, 1,000-1,700 nm), as shown here, can provide contactless brain thermal sensing through the scalp and skull in real-time with a sub-degree resolution. As a proof of concept, Ag2S nanothermometers have been used to monitor brain thermoregulation in a cooling/heating process and temperature changes associated with a barbiturate coma.
Notes
This project has received funding from the European Union's Horizon 2020 FET Open programme under grant agreement No 801305 (NanoTBtech).
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