COMPARISON OF ANTI-MITOTIC AND CYTOTOXIC POTENTIAL OF PIPER CHABA (CHAVAK) AGAINST VINCRISTINE BY USING GERMINATION INHIBITION AND ALLIUM CEPA ROOT TIP ASSAY.

In the present study, we used Vigna radiata germination inhibition and Allium cepa root tip assay to demonstrate the Anti-mitotic and cytotoxic potential of Piper chaba (Chavak) aqueous extract. We compared the effectiveness of the extract with known anti-cancer drugs, vincristine. We observed nearly complete germination inhibition by the plant extract in the Vigna radiata assay. Furthermore, mitotic indices were significantly reduced compared to control. Our study revealed very effective antimitotic as well as cytotoxic activity of the Piper chaba aqueous extract like the vincristine.