3532012
doi
10.5281/zenodo.3532012
oai:zenodo.org:3532012
Orlin Alexandrov
Health Service, Gorna Malina, Bulgaria
Pencho Beykov
Faculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria
Gunay Yetik-Anacak
Department of Pharmacology, Faculty of Pharmacy, Faculty of Pharmacy, Izmir, Turkey
Jelena Krasilnikova
Rigas Stradin University, Riga, Latvia
Gabriela Marinescu
Institute of Physical Chemistry "Ilie Murgulescu", Bucharest, Romania
Daniela-Cristina Culita
Institute of Physical Chemistry "Ilie Murgulescu", Bucharest, Romania
Crtomir Podlipnik
Faculty of Chemistry and Chemical Technology, University of Lubljana, Lubljana, Slovenia
Chukwuemeka Obinna Ekeh
Faculty of Biology, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria
Nonsteroidal anti-inflammatory drugs– What do we (not) know about them
Radostina Alexandrova
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Anticancer, Cyclooxygenase, Non-steroidal anti-inflammatory drugs, Prostanoids, Side effets, Toxicity
<p><strong>Nonsteroidal anti-inflammatory drugs (NSAIDs) reversibly inhibit the functioning of cyclooxygenase (COX) – the rate-limiting enzyme in prostaglandin synthesis, and express anti-inflammatory, antipyretic and analgesic effects. NSAIDs are among the most widely used medications in the world and are prescribed for the treatment of various forms of chronic and acute pain, arthritic conditions, rheumatism, fever/pyrexia, gout, etc. Some of them (aspirin) are used also for prevention of secondary cardiovascular disease due to their ability to suppress platelet aggregation. The mini-review summarizes data about mechanism(s) of action, clinical application and side effects/toxicity of these drugs as well as their potential antitumor activity.</strong></p>
Zenodo
2019-11-07
info:eu-repo/semantics/article
3532011
1579537479.147018
183404
md5:baf754932bca890b32fdbce1022e5ed4
https://zenodo.org/records/3532012/files/Alexandrova et al.pdf
public
10.5281/zenodo.3532011
isVersionOf
doi