3517765
doi
10.5281/zenodo.3517765
oai:zenodo.org:3517765
Romic, Ivan
Pavlek, Goran
Ettinger, Ana
Bajt, Mirna
Colic, Tonko
Malignant transformation of germ cell tumor with teratomatous component into advanced retroperitoneal sarcoma - case report and literature review
Petrovic, Igor
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
sarcoma
retroperitoneal
germ cell tumor
<p><strong>Background: </strong>A late-relapse germ cell tumor (GCT) might contain malignant non-germ cell tumor cells, known as „somatic-type malignancy” (SM). Development of secondary SM is extremely rare and occurs in only 1% of patients with GCT.</p>
<p><strong>Case study: </strong>We present the case of a 42-year-old patient who developed retroperitoneal tumor with duodenal and right colon involvement 6 years after he underwent left orchidectomy for stage IIC mixed GCT (95% seminoma, 5% teratoma). Since the tumor markers for germline tumor were normal, another type of tumor was highly suspected, most likely a malignant alteration of the residual teratoma. Tumor was completely removed and pathological report suggested undifferentiated sarcoma.</p>
<p><strong>Conclusion</strong>: R0 resection and postoperative patient follow-up by the protocol for at least 6 years after orhidectomy is the key to successful treatment of GCT. Malignant tumor transformations are rare, but still possible so clinicians should be aware of the importance of frequent and adequate patient monitoring.</p>
Zenodo
2019-11-03
info:eu-repo/semantics/article
3517764
1579541158.865805
497419
md5:b1a4abe6b33f720b63fdec692c03b16b
https://zenodo.org/records/3517765/files/ACC2019No1 Malignant transformation of germ cell tumor with teratomatous component into advanced retroperitoneal sarcoma.pdf
public
10.5281/zenodo.3517764
isVersionOf
doi
Acta Chirurgica Croatica
1
17-20
2019-11-03