October 21, 2019 Poster Open Access

Maussion, Gilles; Rocha, Cecilia; Soubannier, Vincent

JSON Export

{
  "files": [
    {
      "links": {
        "self": "https://zenodo.org/api/files/d414190f-6f19-4ceb-8eff-5a59775122b4/SFN-2019-POSTER_Final_Gilles%2BCecilia.pdf"
      }, 
      "checksum": "md5:f9a4ab0067cab590a4018976e5686cf1", 
      "bucket": "d414190f-6f19-4ceb-8eff-5a59775122b4", 
      "key": "SFN-2019-POSTER_Final_Gilles+Cecilia.pdf", 
      "type": "pdf", 
      "size": 2198883
    }
  ], 
  "owners": [
    61784
  ], 
  "doi": "10.5281/zenodo.3515460", 
  "stats": {
    "version_unique_downloads": 100.0, 
    "unique_views": 351.0, 
    "views": 363.0, 
    "version_views": 364.0, 
    "unique_downloads": 100.0, 
    "version_unique_views": 352.0, 
    "volume": 235280481.0, 
    "version_downloads": 107.0, 
    "downloads": 107.0, 
    "version_volume": 235280481.0
  }, 
  "links": {
    "doi": "https://doi.org/10.5281/zenodo.3515460", 
    "conceptdoi": "https://doi.org/10.5281/zenodo.3515459", 
    "bucket": "https://zenodo.org/api/files/d414190f-6f19-4ceb-8eff-5a59775122b4", 
    "conceptbadge": "https://zenodo.org/badge/doi/10.5281/zenodo.3515459.svg", 
    "html": "https://zenodo.org/record/3515460", 
    "latest_html": "https://zenodo.org/record/3515460", 
    "badge": "https://zenodo.org/badge/doi/10.5281/zenodo.3515460.svg", 
    "latest": "https://zenodo.org/api/records/3515460"
  }, 
  "conceptdoi": "10.5281/zenodo.3515459", 
  "created": "2019-10-21T20:56:43.143529+00:00", 
  "updated": "2020-01-20T17:17:28.317188+00:00", 
  "conceptrecid": "3515459", 
  "revision": 5, 
  "id": 3515460, 
  "metadata": {
    "access_right_category": "success", 
    "doi": "10.5281/zenodo.3515460", 
    "description": "<p>Fragile X syndrome is a form of syndromic autism whose genetic causes have been relatively well uncovered. It is<br>\nactually mainly caused by a CGG triplet expansion in the 5&rsquo; UTR sequence of FMR1 gene, affecting mostly men. FMR1<br>\nencodes a mRNA binding protein which is involved in the regulation of local translation at the synaptic level. The<br>\nmechanisms leading from such gene mutations to a neurodevelopmental disorder still need to be investigated. While<br>\nseveral studies have shown that the neuronal development is driven by cellular activity and connectivity, we aim to<br>\nfurther investigate the effect of FMR1 repression on the neuronal activity taking advantage of IPSC-derived neurons<br>\nfrom patient&rsquo;s cells. IPSC-derived neurons will be investigated through calcium imaging to characterized their pattern<br>\nof spontaneous activities, as well as their capability to respond to neurotransmitter through extra-synaptic receptors.<br>\nA multielectrode array approach is going to be used to analyse the overall network activities. Those studies should<br>\nprovide further information on the impairment of activity-dependent neuronal development in Fragile X syndrome.</p>", 
    "language": "eng", 
    "title": "Characterization of the activity-dependent development of IPSC-derived neurons from Fragile X patients", 
    "license": {
      "id": "CC-BY-4.0"
    }, 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "3515459"
          }, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "3515460"
          }
        }
      ]
    }, 
    "communities": [
      {
        "id": "sgc-opennotebook"
      }
    ], 
    "version": "V1.0", 
    "keywords": [
      "induced pluripotent stem cells", 
      "cortical neurons", 
      "Fragile X", 
      "Activity", 
      "organoids"
    ], 
    "publication_date": "2019-10-21", 
    "creators": [
      {
        "affiliation": "MNI, McGill University", 
        "name": "Maussion, Gilles"
      }, 
      {
        "affiliation": "MNI, McGill University", 
        "name": "Rocha, Cecilia"
      }, 
      {
        "affiliation": "MNI, McGill University", 
        "name": "Soubannier, Vincent"
      }
    ], 
    "access_right": "open", 
    "resource_type": {
      "type": "poster", 
      "title": "Poster"
    }, 
    "related_identifiers": [
      {
        "scheme": "doi", 
        "identifier": "10.5281/zenodo.3515459", 
        "relation": "isVersionOf"
      }
    ]
  }
}