Journal article Open Access

Effects of Intrauterine Infusion of Autologous platelet rich plasma on Endometrial Thickness, VEGF and Pregnancy Outcome in patients undergoing IUI

Wafaa A. Abaid; Manal T. Al-Obaidi; Muayad S. Abood

Current implantation is a well-orchestrated episode demanding the presence of a well embryo, a compassionate endometrium, suitable embryo endometrial cross-talk, and adequate maternal immune defense. In spite of developments in assisted reproductive technology, there are of no importance advances in the implantation and pregnancy rates. Intrauterine infusion of autologous platelet rich plasma might renew implantation rates through its paracrine properties by progression cytokines and growth factors which facilitate implantation. The aim of current study was to determine whether intrauterine distillation of autologous platelet rich plasma had a role on endometrial receptivity and pregnancy consequence of infertile Iraqi women. This is a randomized prospective study conducted in Higher Institute of Infertility diagnosis and Assisted Reproductive Techniques, AL-Nahrain University in the period from (July 2018 to July 2019). A overall of 43 patients who attend infertility clinic, where prospectively randomly dispersed into two groups. All of them were received Letrozol® tablet orally 2.5 mg twice daily 12 hours apart from day 2 for 5 days for one cycle. 20 women were control while 23 of them were given PRP by intrauterine infusion at day of hCG injection. IUI was done for entirely women in both groups 36-48 hour after confirming ovulation. Blood sample was collected from both groups at the day of IUI for valuation of vascular endothelial growth factor and an ultrasound was done at day of hCG injection and day of IUI for assessment of endometrial thickness. The mean endometrial thickness in PRP group at day of IUI was significantly thicker than that of control group land the difference in percentage change of endometrial thickness between PRP group and controls significantly higher in PRP group. Regarding the VEGF, it was higher than that in controls however. The Pregnancy rate in PRP group was significantly higher than of controls. VEGF was compared across the results of pregnancy tests in both studied group. There was no significant difference had been found neither between nor within groups. Autologous platelet rich plasma intrauterine infusion was safe, well-tolerated and give rise to in significant endometrial thickness expansion after PRP infusion, advance endometrial receptivity by increasing growth factors one of them  in current study was VEGF and increase pregnancy rate in women with infertility underwent ovulation induction and intrauterine insemination.

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