Journal article Open Access

Comparison of Effects of Various Allium Sativum Extracts on Plasma Cholesterol Levels in Hypertensive Rats

Munyikombo Makhacha; Ng'wena-Magak Gideon; Mwaniki Dickson


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    <subfield code="a">Lipolytic; Hypertension; Homogenate; Cholesterol, Therapeutics, Haematological</subfield>
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    <subfield code="u">Department of Medical Physiology. School of Medicine, Maseno University. P.O Box 333. Maseno, Kenya</subfield>
    <subfield code="a">Ng'wena-Magak Gideon</subfield>
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    <subfield code="u">Department of Biological Sciences, School of Science, University of Eldoret. P.O Box 1125 – 30100. Eldoret, Kenya.</subfield>
    <subfield code="a">Mwaniki Dickson</subfield>
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    <subfield code="u">Department of Medical Physiology, School of Medicine and Health Sciences, Kisii University. P. O. Box 408 – 40200. KISII, Kenya</subfield>
    <subfield code="a">Munyikombo Makhacha</subfield>
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    <subfield code="a">Comparison of Effects of Various Allium Sativum Extracts on Plasma Cholesterol Levels in Hypertensive Rats</subfield>
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    <subfield code="a">&lt;p&gt;An agricultural plant &lt;em&gt;Allium sativum&lt;/em&gt; (Garlic) has been shown to have medicinal properties among them blood pressure lowering effects. It is a cultivated member of the Lillaceae family, along with onions, chives, and shallots. Allicin (allyl 2-propenethiosulfinate or diallyl thiosulfonate) are the principal bioactive compounds present in the aqueous extract of &lt;em&gt;Allium sativum&lt;/em&gt; or raw &lt;em&gt;Allium sativum&lt;/em&gt; homogenate.The activity may be dependent on the concentration and the age status of the bioactive components. To analyze the comparative effects of &lt;em&gt;A. sativum&lt;/em&gt; extracts on plasma cholesterol levels on hypertensive rats. Forty eight (n = 48) male wistar rats (250-300g) and 36 weeks old were induced to hypertension. Doses of 50, 100 and 200 mg/kg body weight of &lt;em&gt;A. sativum&lt;/em&gt; were prepared as (Fresh aqueous garlic extract (FAGE-T1), crude garlic extract (CGE-T2) and crude industrial garlic extract (CIGE-T3). These were administered intraperitonially (IP) twice a day for 20 weeks. Blood was collected from the lateral ear vein and plasma cholesterol levels were analyzed. Findings from haematological assays of plasma cholesterol levels in peripheral blood showed that FAGE was more potent in breakdown of cholesterol in peripheral blood and promoted lipolytic mechanisms post-hypertension as compared to groups T2 and T3 with the control was significant at p&amp;le;0.05. Fresh &lt;em&gt;Allium Sativum&lt;/em&gt; provides more insight towards alternative therapeutics and management of hypertension.&lt;/p&gt;</subfield>
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