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Recent advancements in the field of musculoskeletal tissue engineering have raised an increasing interest in the regeneration of the interior cruciate ligament (ACL). It is the aim of this article to review the current research efforts and highlight promising tissue engineering strategies. The four main components of tissue engineering also apply in several ACL regeneration research efforts. Scaffolds from biological materials, biodegradable polymers and composite materials are used. The main cell sources are mesenchymal stem cells and ACL fibroblasts. In addition, growth factors and mechanical stimuli are applied. So far, the regenerated ACL constructs have been tested in a few animal studies and the results are encouraging. The different strategies, from in vitro ACL regeneration in bioreactor systems to bio-enhanced repair and regeneration, are under constant development. We expect considerable progress in the near future that will result in a realistic option for ACL surgery soon.
", "languages": [ { "id": "eng", "title": { "en": "English" } } ], "publication_date": "2015-01-18", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "Anterior Cruciate Ligament" }, { "subject": "Tissue Engineering" }, { "subject": "Orthopedic" }, { "subject": "Ligament Regeneration" }, { "subject": "Stem Cell" } ], "title": "Regeneration of the anterior cruciate ligament: Current strategies in tissue engineering" }, "parent": { "access": { "owned_by": { "user": 72623 } }, "communities": { "default": "aa836685-60ac-46ad-b311-2d9ad869b07f", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2019-07-18T11:42:07.640871+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "aa836685-60ac-46ad-b311-2d9ad869b07f", "links": {}, "metadata": { "curation_policy": "", "page": "Austria’s technical university of applied sciences
\r\n\r\nWith around 11,000 graduates thus far and 4,400 students, the University of Applied Sciences Technikum Wien is Austria’s only purely technical university of applied sciences. The educational offerings consist of 12 bachelor’s and 18 master’s degree programs.
\r\n\r\nIt became a member of the European University Association (EUA) in 2012 and is also a network partner of FEEI – Association of the Electrical and Electronics Industries.
\r\n\r\nhttps://www.technikum-wien.at/en/
\r\n\r\n\r\n\r\n
Austria’s technical university of applied sciences
\r\n\r\nWith around 11,000 graduates thus far and 4,400 students, the University of Applied Sciences Technikum Wien is Austria’s only purely technical university of applied sciences. The educational offerings consist of 12 bachelor’s and 18 master’s degree programs, which are offered as full-time, part-time and/or distance study programs. Four degree programs are taught in English. The educational offerings are based on a solid scientific foundation and are also practice-oriented. At UAS Technikum Wien, emphasis is not only placed on providing a high-quality technical education, but also on subjects with a focus on business and personal development. Close ties and collaborations with business and industry give students and graduates excellent career opportunities. The combination of theory and practical application is of central importance in both research and instruction.
\r\n\r\nThe research and development activities at UAS Technikum Wien have grown significantly in recent years and currently concentrate on our research focuses:
\r\n\r\nUAS Technikum Wien was founded in 1994 and in 2000 it became the first institution in Vienna to receive the status of a university of applied sciences. It became a member of the European University Association (EUA) in 2012 and is also a network partner of FEEI – Association of the Electrical and Electronics Industries.
\r\n\r\n", "title": "University of Applied Sciences Technikum Wien" }, "revision_id": 0, "slug": "fhtw", "updated": "2019-07-18T11:42:07.693881+00:00" } ], "ids": [ "aa836685-60ac-46ad-b311-2d9ad869b07f" ] }, "id": "3460333", "pids": { "doi": { "client": "datacite", "identifier": "10.5281/zenodo.3460333", "provider": "datacite" } } }, "pids": { "doi": { "client": "datacite", "identifier": "10.5281/zenodo.3460334", "provider": "datacite" }, "oai": { "identifier": "oai:zenodo.org:3460334", "provider": "oai" } }, "revision_id": 5, "stats": { "all_versions": { "data_volume": 85528517.0, "downloads": 71, "unique_downloads": 71, "unique_views": 187, "views": 200 }, "this_version": { "data_volume": 85528517.0, "downloads": 71, "unique_downloads": 71, "unique_views": 187, "views": 200 } }, "status": "published", "updated": "2021-04-19T14:09:00.663499+00:00", "versions": { "index": 1, "is_latest": true } }