PsPM-DoxMem2 dataset
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Repository Version: 2019.09.18

This dataset includes eyetracker, skin conductance response (SCR), electrocardiogram (ECG), respiration and electromyogram (EMG, only relevant for retention phase) measurements. Also included are CS and US information, keypress responses and keypress response times for 79 healthy participants (40 males and 39 females aged 24.8+/-4.9 years). Participants underwent a classical (Pavlovian) discriminant delay fear conditioning task with 1 CS- and 2 CS+ (50% reinforcement), were reminded of one CS+ one week later under either doxycycline or placebo, and were tested in a retention/extinction and re-learning task another week later. CS were isoluminant coloured triangles. US consisted of 0.5 s square electric pulses with 0.2 ms duration and 500 Hz frequency. SOA between the CS onset and US was 3.5 s. CS and US co-terminated. Before the fear conditioning task, participants completed several questionnaires. During the retention/extinction phase, an auditory startle probe (ST) and no US was delivered 3.5 s after CS onset via headphones (102 dB, 40 ms duration with 2 ms on- and offset ramp). In an immediately following re-learning phase, the ST was omitted and the CS reinforced with the same schedule as during acquisition. The ITI was randomly determined on each trial to be 7, 9, or 11 s.

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This repository is curated by the PsPM team, pspm.sourceforge.net

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Dataset is described and used in following references:
- Dominik R. Bach & Monika Naef & Markus Deutschmann & Shiva K. Tyagarajan & Boris B. Quednow (2019) Threat memory reminder under matrix metalloproteinase 9 inhibitor doxycycline globally reduces subsequent memory plasticity. Journal of Neuroscience, in press. 

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File Structure:
-README.txt                 // This document
-excludes.txt               // Information on subjects excluded from certain publications
-+Data                      // Folder Containing all data files
|-DoxMem2_wdq_XX_snY.mat    // 237 files holding measurements for SCR, ECG, respiration, EMG
|-DoxMem2_pupil_XX_snY.mat  // 237 files holding measurements for eyetracker
|-DoxMem2_cogent_XX_snY.mat // 237 files holding key presses, CS/US/ST information, demographics and questionnaire scores, and drug information
|-DoxMem2_SetUS_Y.mat       // 79 files holding ratings of the pain stimulus delivered as US

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Data Files:
- Files holding SCR, EMG, ECG, respiration traces and time markers, recorded with WDQ software.
  - Skin conductance (channel 1)
  - Electromyogram (channel 2)
  - Electrocardiogram (channel 3)
  - Respiration (channel 4)
  - Startle sounds (channel 5)
  - Event markers used for synchronization with Cogent files, markers are set at CS presentation onset (channel 6)
- Files holding pupil traces and time markers, recorded with Eyelink software.
   - Event markers used for synchronization with Cogent files, marker are set at CS presentation onset (channel 1)
   - Pupil size for left pupil (channel 2)
   - Gaze coordinate x for left pupil (channel 3)
   - Gaze coordinate y for left pupil (channel 4)
   - Pupil size for right pupil (channel 5)
   - Gaze coordinate x for right pupil (channel 6)
   - Gaze coordinate y for right pupil (channel 7)
- Files holding keyboard presses and CS/US information, recorded with Cogent 2000 software. Also contains demographic (age, sex) and psychometric (BDI, STAI, BISBAS) information, US characteristics (amplitude, perceived by the subject) and drug status on day 2 (0: placebo; 1: 200 mg doxycycline).
- Files holding data from intensity ratings on random electric stimulations, at 4 different time points during the study.

The data file name is composed of:
- DoxMem2                The dataset name
- wdq/pupil/cogent/SetUS The type of data recorded (see above)
- XX                     The subject number
- Y                      The session number

Data are stored as .mat files for use with MATLAB (The MathWorks Inc., Natick, USA) in a format readable by the PsPM toolbox (pspm.sourceforge.net).