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Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.

Coliva, A; Monterisi, C; Apollaro, A; Gatti, D; Penso, M; Gianolli, L; Perani, D; Gilardi, MC; Carpinelli, A


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  <dc:creator>Coliva, A</dc:creator>
  <dc:creator>Monterisi, C</dc:creator>
  <dc:creator>Apollaro, A</dc:creator>
  <dc:creator>Gatti, D</dc:creator>
  <dc:creator>Penso, M</dc:creator>
  <dc:creator>Gianolli, L</dc:creator>
  <dc:creator>Perani, D</dc:creator>
  <dc:creator>Gilardi, MC</dc:creator>
  <dc:creator>Carpinelli, A</dc:creator>
  <dc:date>2015-07-17</dc:date>
  <dc:description>[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.</dc:description>
  <dc:identifier>https://zenodo.org/record/33940</dc:identifier>
  <dc:identifier>10.1016/j.apradiso.2015.07.003</dc:identifier>
  <dc:identifier>oai:zenodo.org:33940</dc:identifier>
  <dc:relation>info:eu-repo/grantAgreement/EC/FP7/278850/</dc:relation>
  <dc:relation>url:https://zenodo.org/communities/inmind</dc:relation>
  <dc:relation>url:https://zenodo.org/communities/ecfunded</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:source>Appl Radiat Isot.  105 66-71 (2015)</dc:source>
  <dc:subject>Cyclotron  </dc:subject>
  <dc:subject>Alzheimer's disease </dc:subject>
  <dc:subject>[11C]MeOTf </dc:subject>
  <dc:subject>[11C]PIB</dc:subject>
  <dc:subject>β-amyloid</dc:subject>
  <dc:title>Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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