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Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.

Coliva, A; Monterisi, C; Apollaro, A; Gatti, D; Penso, M; Gianolli, L; Perani, D; Gilardi, MC; Carpinelli, A


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{
  "description": "<p>[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.</p>", 
  "license": "http://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Vita-Salute S.RaffaeleUniversity,Milan,Italy", 
      "@type": "Person", 
      "name": "Coliva, A"
    }, 
    {
      "affiliation": "CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy", 
      "@type": "Person", 
      "name": "Monterisi, C"
    }, 
    {
      "affiliation": "CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy", 
      "@type": "Person", 
      "name": "Apollaro, A"
    }, 
    {
      "affiliation": "Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy", 
      "@type": "Person", 
      "name": "Gatti, D"
    }, 
    {
      "affiliation": "CNR-ISTM, Milan,Italy", 
      "@type": "Person", 
      "name": "Penso, M"
    }, 
    {
      "affiliation": "Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy", 
      "@type": "Person", 
      "name": "Gianolli, L"
    }, 
    {
      "affiliation": "Vita-Salute S.RaffaeleUniversity,Milan,Italy and CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy", 
      "@type": "Person", 
      "name": "Perani, D"
    }, 
    {
      "affiliation": "CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy and Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy", 
      "@type": "Person", 
      "name": "Gilardi, MC"
    }, 
    {
      "affiliation": "CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy and Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy", 
      "@type": "Person", 
      "name": "Carpinelli, A"
    }
  ], 
  "url": "https://zenodo.org/record/33940", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2015-07-17", 
  "headline": "Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), \u03b2-amyloid PET imaging tracer for Alzheimer's disease diagnosis.", 
  "keywords": [
    "Cyclotron  ", 
    "Alzheimer's disease ", 
    "[11C]MeOTf ", 
    "[11C]PIB", 
    "\u03b2-amyloid"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1016/j.apradiso.2015.07.003", 
  "@id": "https://doi.org/10.1016/j.apradiso.2015.07.003", 
  "@type": "ScholarlyArticle", 
  "name": "Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), \u03b2-amyloid PET imaging tracer for Alzheimer's disease diagnosis."
}
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