Journal article Open Access

Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.

Coliva, A; Monterisi, C; Apollaro, A; Gatti, D; Penso, M; Gianolli, L; Perani, D; Gilardi, MC; Carpinelli, A


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    "doi": "10.1016/j.apradiso.2015.07.003", 
    "description": "<p>[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.</p>", 
    "license": {
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    "title": "Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), \u03b2-amyloid PET imaging tracer for Alzheimer's disease diagnosis.", 
    "journal": {
      "volume": "105", 
      "year": "2015", 
      "pages": "66-71", 
      "title": "Appl Radiat Isot. "
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    "keywords": [
      "Cyclotron  ", 
      "Alzheimer's disease ", 
      "[11C]MeOTf ", 
      "[11C]PIB", 
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    "publication_date": "2015-07-17", 
    "creators": [
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        "affiliation": "Vita-Salute S.RaffaeleUniversity,Milan,Italy", 
        "name": "Coliva, A"
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        "affiliation": "CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy", 
        "name": "Monterisi, C"
      }, 
      {
        "affiliation": "CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy", 
        "name": "Apollaro, A"
      }, 
      {
        "affiliation": "Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy", 
        "name": "Gatti, D"
      }, 
      {
        "affiliation": "CNR-ISTM, Milan,Italy", 
        "name": "Penso, M"
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        "affiliation": "Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy", 
        "name": "Gianolli, L"
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      {
        "affiliation": "Vita-Salute S.RaffaeleUniversity,Milan,Italy and CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy", 
        "name": "Perani, D"
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        "affiliation": "CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy and Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy", 
        "name": "Gilardi, MC"
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