Journal article Open Access

Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.

Coliva, A; Monterisi, C; Apollaro, A; Gatti, D; Penso, M; Gianolli, L; Perani, D; Gilardi, MC; Carpinelli, A


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  <identifier identifierType="URL">https://zenodo.org/record/33940</identifier>
  <creators>
    <creator>
      <creatorName>Coliva, A</creatorName>
      <givenName>A</givenName>
      <familyName>Coliva</familyName>
      <affiliation>Vita-Salute S.RaffaeleUniversity,Milan,Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Monterisi, C</creatorName>
      <givenName>C</givenName>
      <familyName>Monterisi</familyName>
      <affiliation>CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Apollaro, A</creatorName>
      <givenName>A</givenName>
      <familyName>Apollaro</familyName>
      <affiliation>CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy</affiliation>
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      <creatorName>Gatti, D</creatorName>
      <givenName>D</givenName>
      <familyName>Gatti</familyName>
      <affiliation>Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Penso, M</creatorName>
      <givenName>M</givenName>
      <familyName>Penso</familyName>
      <affiliation>CNR-ISTM, Milan,Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Gianolli, L</creatorName>
      <givenName>L</givenName>
      <familyName>Gianolli</familyName>
      <affiliation>Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Perani, D</creatorName>
      <givenName>D</givenName>
      <familyName>Perani</familyName>
      <affiliation>Vita-Salute S.RaffaeleUniversity,Milan,Italy and CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Gilardi, MC</creatorName>
      <givenName>MC</givenName>
      <familyName>Gilardi</familyName>
      <affiliation>CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy and Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Carpinelli, A</creatorName>
      <givenName>A</givenName>
      <familyName>Carpinelli</familyName>
      <affiliation>CNR-IBFM c/oDepartmentofNuclearMedicine,OspedaleSanRaffaele,ViaOlgettina60,20132Milan,Italy and Nuclear MedicineDepartment,IRCCSOspedaleSanRaffaele,Milan,Italy</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2015</publicationYear>
  <subjects>
    <subject>Cyclotron  </subject>
    <subject>Alzheimer's disease </subject>
    <subject>[11C]MeOTf </subject>
    <subject>[11C]PIB</subject>
    <subject>β-amyloid</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2015-07-17</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/33940</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.apradiso.2015.07.003</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/inmind</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/ecfunded</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/278850/">278850</awardNumber>
      <awardTitle>Imaging of Neuroinflammation in Neurodegenerative Diseases</awardTitle>
    </fundingReference>
  </fundingReferences>
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