Journal article Open Access

Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.

Coliva, A; Monterisi, C; Apollaro, A; Gatti, D; Penso, M; Gianolli, L; Perani, D; Gilardi, MC; Carpinelli, A


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{
  "DOI": "10.1016/j.apradiso.2015.07.003", 
  "container_title": "Appl Radiat Isot. ", 
  "title": "Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), \u03b2-amyloid PET imaging tracer for Alzheimer's disease diagnosis.", 
  "issued": {
    "date-parts": [
      [
        2015, 
        7, 
        17
      ]
    ]
  }, 
  "abstract": "<p>[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.</p>", 
  "author": [
    {
      "given": "A", 
      "family": "Coliva"
    }, 
    {
      "given": "C", 
      "family": "Monterisi"
    }, 
    {
      "given": "A", 
      "family": "Apollaro"
    }, 
    {
      "given": "D", 
      "family": "Gatti"
    }, 
    {
      "given": "M", 
      "family": "Penso"
    }, 
    {
      "given": "L", 
      "family": "Gianolli"
    }, 
    {
      "given": "D", 
      "family": "Perani"
    }, 
    {
      "given": "MC", 
      "family": "Gilardi"
    }, 
    {
      "given": "A", 
      "family": "Carpinelli"
    }
  ], 
  "page": "66-71", 
  "volume": "105", 
  "type": "article-journal", 
  "id": "33940"
}
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