Dataset Open Access

Vascular Territory template and atlases in MNI space

Schirmer, Markus D; Giese, Anne-Katrin; Fotiadis, Panagiotis; Etherton, Mark R; Cloonan, Lisa; Viswanathan, Anand; Greenberg, Steven M; Wu, Ona; Rost, Natalia S


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    <subfield code="a">This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 753896 (M.D. Schirmer). This study was supported by the NIH-National Institute of Neurological Disorders and Stroke (K23NS064052, R01NS082285, and R01NS086905), American Heart Association/Bugher Foundation Centers for Stroke Prevention Research, and Deane Institute for Integrative Study of Atrial Fibrillation and Stroke.</subfield>
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    <subfield code="a">&lt;p&gt;&lt;strong&gt;Data&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Sixteen subjects (mean age (sd): 69.6 (8.2); 37.5% female) were recruited to generate a high-resolution template. The cohort consists of twelve stroke-free, non-demented patients with the sporadic form of cerebral amyloid angiopathy (CAA), and similarly-aged healthy controls (n=4). Each participant underwent high-resolution MRI&amp;nbsp;with a Siemens Magnetom Prisma 3T scanner (using a 32-channel head coil) as part of a separate study. The standardized protocol included a Multiecho T1-weighted (voxel size: 1x1x1 mm&lt;sup&gt;3&lt;/sup&gt;; Repetition Time [TR]: 2510 ms), a 3D-FLAIR (voxel size: 0.9x0.9x0.9 mm&lt;sup&gt;3&lt;/sup&gt;; TR: 5000 ms; TE: 356 ms), and a T2-weighted Turbo Spin Echo (voxel size: 0.5x0.5x2.0 mm&lt;sup&gt;3&lt;/sup&gt;; TR: 7500 ms; TE: 84 ms) sequence. Scans were manually assessed to ensure no gross pathology was present, such as hemorrhage or silent brain infarcts.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Template and territorial map creation&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;We employed Advanced Normalization Tools (ANTs) for image processing (Avants et al., 2010, 2011) for creating a brain template based on multimodal information using T1, T2 and 3D-FLAIR sequences. After template creation, we smoothed the resulting templates (FSL; Gaussian smoothing, sigma = 1) and registered the resulting templates into MNI space, again using ANTs (Avants et al., 2011).&lt;/p&gt;

&lt;p&gt;Vascular territories were outlined on the right hemisphere in the T1-weighted atlas image and contain anatomically validated ACA, MCA, and PCA territories supratentorially. The right hemispheric map was then mirrored onto the left hemisphere to create a full-brain vascular territory map, which was manually assessed and corrected where necessary.&lt;/p&gt;

&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;For more details, please see the original publication that utilized the template. If you utilize this template, please also cite&lt;/p&gt;

&lt;p&gt;Schirmer, Markus D., et al. &amp;quot;Spatial signature of white matter hyperintensities in stroke patients.&amp;quot; &lt;em&gt;Frontiers in neurology&lt;/em&gt; 10 (2019): 208.&lt;/p&gt;

&lt;p&gt;&lt;a href="https://doi.org/10.3389/fneur.2019.00208"&gt;https://doi.org/10.3389/fneur.2019.00208&lt;/a&gt;&lt;/p&gt;

&lt;p&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Files&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;FLAIR template&lt;/strong&gt;: caa_flair_in_mni_template_smooth.nii.gz&lt;br&gt;
&lt;br&gt;
&lt;strong&gt;FLAIR template after brain extraction and intensity normalization&lt;/strong&gt;: caa_flair_in_mni_template_smooth_brain_intres.nii.gz&lt;br&gt;
&lt;br&gt;
&lt;strong&gt;T1 template&lt;/strong&gt;: caa_t1_in_mni_template_smooth.nii.gz 27.7 Mb&lt;br&gt;
&lt;br&gt;
&lt;strong&gt;T2 template&lt;/strong&gt;: caa_t2_in_mni_template_smooth.nii.gz 27.7 Mb&lt;br&gt;
&lt;br&gt;
&lt;strong&gt;Vascular territory map&lt;/strong&gt;: mni_vascular_territories.nii.gz&lt;/p&gt;</subfield>
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