Dataset Open Access

Vascular Territory template and atlases in MNI space

Schirmer, Markus D; Giese, Anne-Katrin; Fotiadis, Panagiotis; Etherton, Mark R; Cloonan, Lisa; Viswanathan, Anand; Greenberg, Steven M; Wu, Ona; Rost, Natalia S


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{
  "inLanguage": {
    "alternateName": "eng", 
    "@type": "Language", 
    "name": "English"
  }, 
  "description": "<p><strong>Data</strong></p>\n\n<p>Sixteen subjects (mean age (sd): 69.6 (8.2); 37.5% female) were recruited to generate a high-resolution template. The cohort consists of twelve stroke-free, non-demented patients with the sporadic form of cerebral amyloid angiopathy (CAA), and similarly-aged healthy controls (n=4). Each participant underwent high-resolution MRI&nbsp;with a Siemens Magnetom Prisma 3T scanner (using a 32-channel head coil) as part of a separate study. The standardized protocol included a Multiecho T1-weighted (voxel size: 1x1x1 mm<sup>3</sup>; Repetition Time [TR]: 2510 ms), a 3D-FLAIR (voxel size: 0.9x0.9x0.9 mm<sup>3</sup>; TR: 5000 ms; TE: 356 ms), and a T2-weighted Turbo Spin Echo (voxel size: 0.5x0.5x2.0 mm<sup>3</sup>; TR: 7500 ms; TE: 84 ms) sequence. Scans were manually assessed to ensure no gross pathology was present, such as hemorrhage or silent brain infarcts.</p>\n\n<p><strong>Template and territorial map creation</strong></p>\n\n<p>We employed Advanced Normalization Tools (ANTs) for image processing (Avants et al., 2010, 2011) for creating a brain template based on multimodal information using T1, T2 and 3D-FLAIR sequences. After template creation, we smoothed the resulting templates (FSL; Gaussian smoothing, sigma = 1) and registered the resulting templates into MNI space, again using ANTs (Avants et al., 2011).</p>\n\n<p>Vascular territories were outlined on the right hemisphere in the T1-weighted atlas image and contain anatomically validated ACA, MCA, and PCA territories supratentorially. The right hemispheric map was then mirrored onto the left hemisphere to create a full-brain vascular territory map, which was manually assessed and corrected where necessary.</p>\n\n<p>&nbsp;</p>\n\n<p>For more details, please see the original publication that utilized the template. If you utilize this template, please also cite</p>\n\n<p>Schirmer, Markus D., et al. &quot;Spatial signature of white matter hyperintensities in stroke patients.&quot; <em>Frontiers in neurology</em> 10 (2019): 208.</p>\n\n<p><a href=\"https://doi.org/10.3389/fneur.2019.00208\">https://doi.org/10.3389/fneur.2019.00208</a></p>\n\n<p>&nbsp;</p>\n\n<p><strong>Files</strong></p>\n\n<p><strong>FLAIR template</strong>: caa_flair_in_mni_template_smooth.nii.gz<br>\n<br>\n<strong>FLAIR template after brain extraction and intensity normalization</strong>: caa_flair_in_mni_template_smooth_brain_intres.nii.gz<br>\n<br>\n<strong>T1 template</strong>: caa_t1_in_mni_template_smooth.nii.gz 27.7 Mb<br>\n<br>\n<strong>T2 template</strong>: caa_t2_in_mni_template_smooth.nii.gz 27.7 Mb<br>\n<br>\n<strong>Vascular territory map</strong>: mni_vascular_territories.nii.gz</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA", 
      "@id": "https://orcid.org/0000-0001-9561-0239", 
      "@type": "Person", 
      "name": "Schirmer, Markus D"
    }, 
    {
      "affiliation": "Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA", 
      "@id": "https://orcid.org/0000-0002-8500-2376", 
      "@type": "Person", 
      "name": "Giese, Anne-Katrin"
    }, 
    {
      "affiliation": "Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA", 
      "@type": "Person", 
      "name": "Fotiadis, Panagiotis"
    }, 
    {
      "affiliation": "Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA", 
      "@type": "Person", 
      "name": "Etherton, Mark R"
    }, 
    {
      "affiliation": "Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA", 
      "@type": "Person", 
      "name": "Cloonan, Lisa"
    }, 
    {
      "affiliation": "Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA", 
      "@type": "Person", 
      "name": "Viswanathan, Anand"
    }, 
    {
      "affiliation": "Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA", 
      "@type": "Person", 
      "name": "Greenberg, Steven M"
    }, 
    {
      "affiliation": "Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA", 
      "@type": "Person", 
      "name": "Wu, Ona"
    }, 
    {
      "affiliation": "Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA", 
      "@type": "Person", 
      "name": "Rost, Natalia S"
    }
  ], 
  "url": "https://zenodo.org/record/3379848", 
  "datePublished": "2019-03-19", 
  "version": "1.0.0", 
  "keywords": [
    "Brain", 
    "template", 
    "vascular territories", 
    "anterior", 
    "posterior", 
    "middle", 
    "cerebral artery", 
    "ACA", 
    "PCA", 
    "MCA", 
    "MNI", 
    "T1", 
    "T2", 
    "FLAIR"
  ], 
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  "identifier": "https://doi.org/10.5281/zenodo.3379848", 
  "@id": "https://doi.org/10.5281/zenodo.3379848", 
  "@type": "Dataset", 
  "name": "Vascular Territory template and atlases in MNI space"
}
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